Hexamidine Diisethionate

INCI: HEXAMIDINE DIISETHIONATE

CAS Number
659-40-5
Function
Preservative, antimicrobial, anti-dandruff
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.1%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR-assessed safe at concentrations up to 0.1%; used in skin, hair, and nail products

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Effective broad-spectrum preservative regulated under EU Annex V at maximum 0.1% concentration with well-established safety profile and good tolerability in most users.

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Concern Level: Low

Regulatory Flags

preservative regulated antimicrobial annex-v

Frequently Asked Questions

Is Hexamidine Diisethionate safe in cosmetics?

Effective broad-spectrum preservative regulated under EU Annex V at maximum 0.1% concentration with well-established safety profile and good tolerability in most users. The EU classifies Hexamidine Diisethionate as "restricted". Safety rating: GOOD.

Is Hexamidine Diisethionate allowed in the EU?

Hexamidine Diisethionate EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexamidine Diisethionate do in cosmetics?

Hexamidine Diisethionate functions as: Preservative, antimicrobial, anti-dandruff. It is classified as a cosmetic ingredient in our database. CAS number: 659-40-5.

What is the Margin of Safety for Hexamidine Diisethionate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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