Is Hexamidine Diisethionate safe in cosmetics?
Hexamidine Diisethionate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Hexamidine Diisethionate
Also known as: Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,6-hexanediylbis(oxy)]bis[benzenecarboximidamide] (2:1), Benzamidine, 4,4'-(hexamethylenedioxy)di-, diisethionate, EINECS No.: 211-533-5, Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1), Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (+14 more)
INCI: HEXAMIDINE DIISETHIONATE
Hexamidine Diisethionate (CAS 659-40-5) is a cosmetic cosmetic ingredient functioning as Preservative, antimicrobial, anti-dandruff. EU Regulation 1223/2009 status: restricted, max 0.1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 659-40-5 →
Auto-generated CPSR Part A draft with source citations
Function
Preservative, antimicrobial, anti-dandruff
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;bis(2-hydroxyethanesulfonic acid)
InChIKey
NBVZMBLJRHUOJR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.1%
US US Status
permitted
US Notes
CIR-assessed safe at concentrations up to 0.1%; used in skin, hair, and nail products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexamidine Diisethionate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | permitted_preservative | 0.1 | all cosmetics |
| BR | permitted_preservative | 0.1 | - |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
deodorant
{"cas_number": "659-40-5", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "12-24", "odor_reduction_pct": "50-70", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "broad_spectrum", "microbiome_impact": "selective", "axillary_microbiome_effect": "va…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Defoamer
Preservative
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Hexamidine Diisethionate.
Regulatory Flags
preservative
regulated
antimicrobial
annex-v
Known Synonyms
Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,6-hexanediylbis(oxy)]bis[benzenecarboximidamide] (2:1)
Benzamidine, 4,4'-(hexamethylenedioxy)di-, diisethionate
EINECS No.: 211-533-5
Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1)
Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine
Benzamidine, 4,4'-(hexamethylenedioxy)di-, bis(2-hydroxyethanesulfonate)
Benzenecarboximidamide, 4,4'-[1,6-hexanediylbis(oxy)]bis-, bis(2-hydroxyethanesulfonate)
2535RP
Desomedine
Elastab HP 100
Elestab HP 100
Esomedina
Hexamethylenedioxy-4,4'-dibenzamidinebis(hydroxy-2-ethanesulfonate)
Hexamidine isethionate
Hexomedine
NSC 115848
Ophtamedine
RP 2535
p,p'-(Hexamethylenedioxy)dibenzamide bis(β-hydroxyethanesulfonate)
Chemical Function
Softener and conditioner
Preservative
Defoamer
Biocide
Regulatory Lists
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hexamidine Diisethionate allowed in the EU?
Hexamidine Diisethionate EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexamidine Diisethionate do in cosmetics?
Hexamidine Diisethionate functions as: Preservative, antimicrobial, anti-dandruff. It is classified as a cosmetic ingredient in our database. CAS number: 659-40-5.
Is Hexamidine Diisethionate used outside cosmetics?
Hexamidine Diisethionate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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