NOAEL Data REACH Registered Cosmetic Ingredient

Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2)

Also known as: 2-(2,4-Diaminophenoxy)ethanol hydrochloride, EINECS 266-357-1, UNII-Z5Y843J6KQ

CAS 66422-95-5

Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) (CAS 66422-95-5) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2,4-Diaminophenoxyethanol HCl →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields

Name

Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2)

CAS Number

66422-95-5

Molecular Formula

C8H12N2O2.2ClH

InChI Key

VXYWXJXCQSDNHX-UHFFFAOYSA-N

Monoisotopic Mass

240.043233

Synonyms

2-(2,4-Diaminophenoxy)ethanol hydrochlorideEINECS 266-357-1UNII-Z5Y843J6KQ

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
-	Danish Environmental Protection Agency	Danish EPA
-	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
20	mg/kg/day	-	-	-	Regulatory source
20	mg/kg/day	-	-	human	Regulatory source
=0.7	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
5.5	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
Z5Y843J6KQ	UNII	FDA UNII substance identifier	-	-	openFDA substances
20	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
125	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.051	mg/kg	NOAEL	oral	rat	SCCS Opinion
4	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
20	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=20	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=20	mg/kg/day	NOAEL	-	-	SCCS Opinion
=20	mg/kg	NOAEL	oral	rat	SCCS Opinion
=20	mg/kg bw/day	NOEL	oral	Rat	ECHA
=0.051	mg/kg	developmental toxicity	oral	rat	Regulatory source
=20	mg/kg	developmental toxicity	oral	rat	Regulatory source
20	mg/kg bw/day	developmental toxicity	oral	rat	Regulatory source

Showing 17 of 17 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-(2,4-diaminophenoxy)ethanol dihydrochloride	266-357-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1410/10	21 September 2010	safe	2.0%	strong sensitiser; MoS adequate
SCCP/0910/05	28 March 2006	safe	2.0%	strong sensitiser; MoS adequate
SCCS/1367/10	21 September 2010	The SCCS is of the opinion that the use of 2,4-diaminophenoxyethanol dihydrochloride or 2,4-diaminophenoxyethanol sulfate in an oxidative hair dye formulation at a maximum final concentration of 2.0% (after mixing with hydrogen peroxide) does not pose a risk to the health of the consumer, apart from its sensitising potential.	2.0% (final on-head, after mixing with hydrogen peroxide)	Sensitising potential. Genotoxicity/mutagenicity studies in finished formulations should be undertaken per SCCNFP opinions and Notes of Guidance.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

2.0%

Frequently Asked Questions

What is the NOAEL for Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2)?

Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) has 17 NOAEL studies in the database. The lowest reported value is 0.051 mg/kg via oral in rat. Source: SCCS Opinion.

What regulatory lists include Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2)?

Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) appears on 3 regulatory/inventory lists including Europe; Personal care - hair coloring, detected; Europe; Personal care - hair coloring - hair color - professional, detected; Europe; Personal care - hair coloring. Source: EPA CPDat.

Is Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) used in cosmetics?

Yes, Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) is also indexed as a cosmetic ingredient under the name 2,4-Diaminophenoxyethanol HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) used outside industrial chemicals?

Ethanol, 2-(2,4-diaminophenoxy)-, hydrochloride (1:2) also appears in cosmetics databases.