2,4-Diaminophenoxyethanol HCl
INCI: 2,4-DIAMINOPHENOXYETHANOL HCL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for 2,4-Diaminophenoxyethanol HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 20 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| LOAEL | 125 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Concentration limits strictly enforced; eyelash dye use limited to professionals; must carry "Can cause allergic reaction" label
Frequently Asked Questions
Is 2,4-Diaminophenoxyethanol HCl safe in cosmetics?
Concentration limits strictly enforced; eyelash dye use limited to professionals; must carry "Can cause allergic reaction" label The EU classifies 2,4-Diaminophenoxyethanol HCl as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is 2,4-Diaminophenoxyethanol HCl allowed in the EU?
2,4-Diaminophenoxyethanol HCl EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,4-Diaminophenoxyethanol HCl do in cosmetics?
2,4-Diaminophenoxyethanol HCl functions as: Oxidative hair dye (primary intermediate/coupler). It is classified as a cosmetic ingredient in our database. CAS number: 66422-95-5.
What is the Margin of Safety for 2,4-Diaminophenoxyethanol HCl?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2,4-Diaminophenoxyethanol HCl?
The NOAEL (No Observed Adverse Effect Level) for 2,4-Diaminophenoxyethanol HCl is 4 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check 2,4-Diaminophenoxyethanol HCl compliance across multiple jurisdictions:
Related Ingredients
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