What is the NOAEL for 3-(p-Cumenyl)-2-methylpropionaldehyde?
3-(p-Cumenyl)-2-methylpropionaldehyde has 12 NOAEL studies in the database. The lowest reported value is 0.529 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-(p-Cumenyl)-2-methylpropionaldehyde
Also known as: Benzenepropanal, .alpha.-methyl-4-(2-methylpropyl)-, Benzenepropanal, alpha-methyl-4-(2-methylpropyl)-, 2-Methyl-3-[4-(2-methylpropyl)phenyl]propanal, p-Isobutyl-alpha-methyl hydrocinnamaldehyde, EINECS 229-695-0 (+4 more)
CAS 6658-48-6
3-(p-Cumenyl)-2-methylpropionaldehyde (CAS 6658-48-6) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 3-(P-Cumenyl)-2-Methylpropionaldehyde →
Cross-Vertical Regulatory Divergence
3-(p-Cumenyl)-2-methylpropionaldehyde is classified GHS CMR hazard (H317, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
3-(p-Cumenyl)-2-methylpropionaldehyde
CAS Number
6658-48-6
DTXSID
DTXSID4052346
Molecular Formula
C14H20O
InChI Key
YLIXVKUWWOQREC-UHFFFAOYSA-N
Monoisotopic Mass
204.151415
Synonyms
Benzenepropanal, .alpha.-methyl-4-(2-methylpropyl)-Benzenepropanal, alpha-methyl-4-(2-methylpropyl)-2-Methyl-3-[4-(2-methylpropyl)phenyl]propanalp-Isobutyl-alpha-methyl hydrocinnamaldehydeEINECS 229-695-0SilvialBenzenepropanal, α-methyl-4-(2-methylpropyl)-Hydrocinnamaldehyde, p-isobutyl-α-methyl-Suzaral
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
26 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 71.8 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 256 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =0.529 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| Z3NXK8Y7EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z3NXK8Y7EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z3NXK8Y7EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z3NXK8Y7EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 86.1 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.03 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =275 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =300 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-(p-cumenyl)-2-methylpropionaldehyde | 229-695-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Frequently Asked Questions
What regulatory lists include 3-(p-Cumenyl)-2-methylpropionaldehyde?
3-(p-Cumenyl)-2-methylpropionaldehyde appears on 2 regulatory/inventory lists including Europe, IFRA Transparency. Source: EPA CPDat.
Is 3-(p-Cumenyl)-2-methylpropionaldehyde used in cosmetics?
Yes, 3-(p-Cumenyl)-2-methylpropionaldehyde is also indexed as a cosmetic ingredient under the name 3-(P-Cumenyl)-2-Methylpropionaldehyde. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-(p-Cumenyl)-2-methylpropionaldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 3-(p-Cumenyl)-2-methylpropionaldehyde have different safety status in cosmetics vs industrial chemicals?
3-(p-Cumenyl)-2-methylpropionaldehyde is classified GHS CMR hazard (H317, H361) in the chemicals database but is allowed in EU cosmetics.
Is 3-(p-Cumenyl)-2-methylpropionaldehyde used outside industrial chemicals?
3-(p-Cumenyl)-2-methylpropionaldehyde also appears in cosmetics databases.