Moderate Cosmetic Ingredient NOAEL Data

3-(P-Cumenyl)-2-Methylpropionaldehyde

INCI: 3-(P-CUMENYL)-2-METHYLPROPIONALDEHYDE

CAS Number
6658-48-6
Function
Fragrance (perfuming)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically restricted by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 3-(P-Cumenyl)-2-Methylpropionaldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day dermal rat dermal REACH

Expert Verdict

GHS H361: Suspected of damaging fertility or the unborn child; classified skin sensitizer and suspected reproductive toxicant

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Concern Level: High

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is 3-(P-Cumenyl)-2-Methylpropionaldehyde safe in cosmetics?

GHS H361: Suspected of damaging fertility or the unborn child; classified skin sensitizer and suspected reproductive toxicant The EU classifies 3-(P-Cumenyl)-2-Methylpropionaldehyde as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is 3-(P-Cumenyl)-2-Methylpropionaldehyde allowed in the EU?

3-(P-Cumenyl)-2-Methylpropionaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-(P-Cumenyl)-2-Methylpropionaldehyde do in cosmetics?

3-(P-Cumenyl)-2-Methylpropionaldehyde functions as: Fragrance (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 6658-48-6.

What is the Margin of Safety for 3-(P-Cumenyl)-2-Methylpropionaldehyde?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 3-(P-Cumenyl)-2-Methylpropionaldehyde?

The NOAEL (No Observed Adverse Effect Level) for 3-(P-Cumenyl)-2-Methylpropionaldehyde is 300 mg/kg bw/day based on a dermal study via dermal route in rat. Source: REACH.

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