Also known as: Benzenepropanal, .alpha.-methyl-4-(2-methylpropyl)-, Benzenepropanal, alpha-methyl-4-(2-methylpropyl)-, 2-Methyl-3-[4-(2-methylpropyl)phenyl]propanal, p-Isobutyl-alpha-methyl hydrocinnamaldehyde, EINECS 229-695-0 (+4 more)
INCI: 3-(P-CUMENYL)-2-METHYLPROPIONALDEHYDE
3-(P-Cumenyl)-2-Methylpropionaldehyde (CAS 6658-48-6) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming). NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 6658-48-6 →
3-(P-Cumenyl)-2-Methylpropionaldehyde is classified GHS CMR hazard (H317, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-(P-Cumenyl)-2-Methylpropionaldehyde.
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for 3-(P-Cumenyl)-2-Methylpropionaldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | dermal | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-calculated NOAEL → SED → MoS audit trail for 3-(P-Cumenyl)-2-Methylpropionaldehyde across SCCS product categories, with measured dermal absorption where available.
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: Report to RIFM by Givaudan (RIFM DB#41055); DPRA: Hoffmann et al., 2018; KS: No reference provided in NICEATM database; hCLAT: No reference provided in NICEATM database
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 104 | 0 | 2362 | 2362 | non-sensitizer |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Expert safety assessment and concern-level summary for 3-(P-Cumenyl)-2-Methylpropionaldehyde.
Public NOAEL study rows linked to 3-(P-Cumenyl)-2-Methylpropionaldehyde by CAS number or substance name.
3-(P-Cumenyl)-2-Methylpropionaldehyde has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
3-(P-Cumenyl)-2-Methylpropionaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
3-(P-Cumenyl)-2-Methylpropionaldehyde functions as: Fragrance (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 6658-48-6.
The NOAEL (No Observed Adverse Effect Level) for 3-(P-Cumenyl)-2-Methylpropionaldehyde is =300 mg/kg bw/day based on a short-term study via dermal route in Rat. Source: ToxValDB_ECHA_IUCLID.
3-(P-Cumenyl)-2-Methylpropionaldehyde also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
3-(P-Cumenyl)-2-Methylpropionaldehyde is classified GHS CMR hazard (H317, H361) in the chemicals database but is allowed in EU cosmetics.
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