NOAEL Data REACH Registered Cosmetic Ingredient

2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride

Also known as: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride, (β-Hydroxyethyl)trimethylammonium chloride, Bilineurin chloride, Choline chloride, Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1) (+12 more)

CAS 67-48-1

2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride (CAS 67-48-1) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Choline Chloride →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride

CAS Number

67-48-1

DTXSID

DTXSID4020325

Molecular Formula

C5H14NO.ClH

InChI Key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

Monoisotopic Mass

140.084217

Synonyms

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride(β-Hydroxyethyl)trimethylammonium chlorideBilineurin chlorideCholine chlorideEthanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (2-Hydroxyethyl)trimethylammonium chlorideAmmonium, (2-hydroxyethyl)trimethyl-, chlorideEINECS 200-655-4NSC 402838Chloride de cholineCholini chloridumColina cloruro

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

Surfactant (surface active agent)Anti-static agentHumectantSoftener and conditionerStabilizing agentFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records

List	Keyword	Source
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
fracking	FracFocus	FracFocus
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 12 of 12 studies

Value	Unit	Endpoint	Route	Species	Source
=194.54	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
45I14D8O27	UNII	FDA UNII substance identifier	-	-	openFDA substances
45I14D8O27	UNII	FDA UNII substance identifier	-	-	openFDA substances
45I14D8O27	UNII	FDA UNII substance identifier	-	-	openFDA substances
45I14D8O27	UNII	FDA UNII substance identifier	-	-	openFDA substances
=3400	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=6640	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
10	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
700	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1200	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
1350	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB

Showing 12 of 12 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Choline chloride	200-655-4	ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1134/08	15 April 2008	safe with restrictions	Various	Precursor to acetylcholine; low toxicity at cosmetic use levels; no significant concern

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHOLINE CHLORIDE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E1001i — ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride?

2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride has 12 NOAEL studies in the database. The lowest reported value is 194.54 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride?

2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, inert_ingredient; Pesticides, and 5 more. Source: EPA CPDat.

Is 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride used in cosmetics?

Yes, 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride is also indexed as a cosmetic ingredient under the name Choline Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride used outside industrial chemicals?

2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.