Also known as: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride, (β-Hydroxyethyl)trimethylammonium chloride, Bilineurin chloride, Choline chloride, Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1) (+12 more)
CAS 67-48-1
2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride (CAS 67-48-1) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH, ILO ICSC.
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| fracking | FracFocus | FracFocus |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| banned; Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =194.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 45I14D8O27 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3400 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =6640 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 10 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 700 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1200 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 1350 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
Showing 9 of 9 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Choline chloride | 200-655-4 | ECHA overview → |
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1134/08 | 15 April 2008 | safe with restrictions | Various | Precursor to acetylcholine; low toxicity at cosmetic use levels; no significant concern |
| SCCP/1159/08 | 2008-04-15 | The SCCP is of the opinion that the study included in the present submission is not sufficient to answer the concerns about mucous membrane irritation. Before any further consideration, the following information is required: a study on mucous membrane irritation at the intended use concentration of 5%, in accordance with the SCCP Notes of Guidance. | - | Mucous membrane (eye) irritation concern unresolved; choline chloride was tested at only 0.5% instead of the requested use concentration of 5%; BCOP assay is a screening method not suitable for risk characterisation; additional mucous membrane irritation study at 5% required. |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
E1001i — ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride has 9 NOAEL studies in the database. The lowest reported value is 194.5 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, inert_ingredient; Pesticides, and 5 more. Source: EPA CPDat.
Yes, 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride is also indexed as a cosmetic ingredient under the name Choline Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.