Choline Chloride
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Choline Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1200 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1350 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 700 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| dose_tested | 1200 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| dose_tested | 700 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Regulatory Flags
Frequently Asked Questions
Is Choline Chloride safe in cosmetics?
Choline Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 7 toxicological study endpoint(s) are available in our database.
Is Choline Chloride allowed in the EU?
Choline Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Choline Chloride do in cosmetics?
Choline Chloride functions as: Anti-static agent; Flavouring and nutrient; Humectant; Softener and conditioner; Stabilizing agent; Surfactant (surface active agent). It is classified as a cosmetic ingredient in our database. CAS number: 67-48-1.
What is the Margin of Safety for Choline Chloride?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Choline Chloride?
The NOAEL (No Observed Adverse Effect Level) for Choline Chloride is 1200 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 7 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Choline Chloride compliance across multiple jurisdictions:
Related Ingredients
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