Is Choline Chloride safe in cosmetics?
Choline Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Choline Chloride
Also known as: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride, 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride, (β-Hydroxyethyl)trimethylammonium chloride, Bilineurin chloride, Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1) (+12 more)
Choline Chloride (CAS 67-48-1) is a cosmetic cosmetic ingredient functioning as Anti-static agent; Flavouring and nutrient; Humectant; Softener and. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 67-48-1 →
Auto-generated CPSR Part A draft with source citations
Function
Anti-static agent; Flavouring and nutrient; Humectant; Softener and conditioner; Stabilizing agent; Surfactant (surface active agent)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-hydroxyethyl(trimethyl)azanium chloride
InChIKey
SGMZJAMFUVOLNK-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: SQ - IJT 31(Suppl. 3):296-341, 2012
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Choline Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 168
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 168
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0853
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Number
2003
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CHOLINE CHLORIDE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/49 | FAS 64-JECFA 73/119
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Humectant
Softener and conditioner
Stabilizing agent
Surfactant (surface active agent)
Regulatory List Membership (3)
EU Banned in Cosmetics
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Choline Chloride.
Regulatory Flags
eu_banned_cosmetics
fda_food_additive
eu_cosing_listed
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Choline Chloride by CAS number or substance name.
Studies
3
Lowest NOAEL
4160 mg/kg bw/day
Highest NOAEL
4160 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride
(β-Hydroxyethyl)trimethylammonium chloride
Bilineurin chloride
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (2-Hydroxyethyl)trimethylammonium chloride
Ammonium, (2-hydroxyethyl)trimethyl-, chloride
EINECS 200-655-4
NSC 402838
Chloride de choline
Cholini chloridum
Colina cloruro
UNII-45I14D8O27
(beta-Hydroxyethyl)trimethylammonium chloride
2-Hydroxy-N,N,N,-trimethylethanaminium chloride
Choline chlorhydrate
Choline hydrochloride
Chemical Function
Surfactant (surface active agent)
Anti-static agent
Humectant
Softener and conditioner
Stabilizing agent
Flavouring and nutrient
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
pharmaceutical
pharmaceutical
fracking
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
banned; Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHOLINE CHLORIDE
ChEMBL ID
CHEMBL282468
Max Phase
4
Frequently Asked Questions
Is Choline Chloride allowed in the EU?
Choline Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Choline Chloride do in cosmetics?
Choline Chloride functions as: Anti-static agent; Flavouring and nutrient; Humectant; Softener and conditioner; Stabilizing agent; Surfactant (surface active agent). It is classified as a cosmetic ingredient in our database. CAS number: 67-48-1.
Is Choline Chloride used outside cosmetics?
Choline Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Choline Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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