Also known as: Isopropyl alcohol, 2-Propanol, 4-01-00-01461, Alcosolve, Arquad DMCB (+15 more)
CAS 67-63-0
Isopropanol (CAS 67-63-0) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H336; H319. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Isopropanol is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 15, Sup 7, 71 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; STOT SE 3; Eye Irrit. 2 | H225; H336; H319 | GHS02; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Causes serious eye irritation May cause drowsiness or dizziness |
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dryness and cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 400 ppm (980 mg/m³) | 400 | 980 | N |
| NIOSH | TWA | 400 ppm (980 mg/m³) | 400 | 980 | N |
| NIOSH | STEL | 500 ppm (1225 mg/m³) | 500 | 1225 | N |
| ACGIH | TWA | 200 ppm [2001] | 200 | - | N |
| ACGIH | STEL | 400 ppm [2001] | 400 | - | N |
| CAL/OSHA | TWA | 400 ppm (980 mg/m³) | 400 | 980 | N |
| CAL/OSHA | STEL | 500 ppm (1225 mg/m³) | 500 | 1225 | N |
| NIOSH | IDLH | 2000 ppm | 2000 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| fracking | FracFocus | FracFocus |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| fracking; water | NY Department of Conservation | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.4 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =2.4 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =55.2 | mg/kg bw/day | BMDL (05 HED) | oral | Rabbit | ToxValDB_PPRTV_(CPHEA) |
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >420.672 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 2000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| >5000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.102 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 5.972 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =500 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| -10 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.5 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 5 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 6.1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 9.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 9.9 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 10.8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -1.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.2 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.5 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.6 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.9 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.25 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.4 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.45 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.8 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.85 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.4 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 3.05 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 3.65 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 4.75 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 5.2 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 5.75 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 30.5 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| 4 | unitless | EPA classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =4 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| ND2M416302 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ND2M416302 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propan-2-ol | 200-661-7 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Isopropyl alcohol (strong acid process only) | - | - |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Isopropanol (CAS 67-63-0) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H225; H336; H319. Source: EU CLP Annex VI (ECHA).
Isopropanol has 100 NOAEL studies in the database. The lowest reported value is -10 % via Dermal. Source: NTP_ICE_skin_sensitization.
Isopropanol appears on 28 regulatory/inventory lists including inert_ingredient; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Europe; Pesticides, and 25 more. Source: EPA CPDat.
Isopropanol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Isopropanol are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Isopropanol is also indexed as a cosmetic ingredient under the name Isopropanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Isopropanol is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.
Isopropanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.