Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Isopropanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 7 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | monkey | Chronic | COSMOS_DB |
| NOAEL | 466 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 625 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1200 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1280 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1200 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 601 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Well-established cosmetic solvent and astringent safe at normal use concentrations; avoid eye contact and inhalation of concentrated vapors.
Regulatory Flags
Frequently Asked Questions
Is Isopropanol safe in cosmetics?
Well-established cosmetic solvent and astringent safe at normal use concentrations; avoid eye contact and inhalation of concentrated vapors. The EU classifies Isopropanol as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Isopropanol allowed in the EU?
Isopropanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropanol do in cosmetics?
Isopropanol functions as: Solvent, Antifoaming, Cosmetic Astringent, Viscosity Decreasing. It is classified as a cosmetic ingredient in our database. CAS number: 67-63-0.
What is the Margin of Safety for Isopropanol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isopropanol?
The NOAEL (No Observed Adverse Effect Level) for Isopropanol is 7 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Isopropanol classified as hazardous under GHS?
Isopropanol carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Causes serious eye irritation May cause drowsiness or dizziness. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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