NOAEL Data Cosmetic Ingredient

Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1)

CAS 67846-56-4

Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) (CAS 67846-56-4) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for Basic Blue 124 →

SOURCE NOAEL studies
NOAEL studies
14
SOURCE Chemical inventory jurisdictions
Regulatory lists
1
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 5 fields
Name
Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1)
CAS Number
67846-56-4
Molecular Formula
C15H16N3O2.ClH
InChI Key
IQWZDDMJNAILMK-UHFFFAOYSA-M
Monoisotopic Mass
306.100929

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 14 of 14 studies
ValueUnitEndpointRouteSpeciesSource
=0.00032mg/kg bwNOAELoralratSCCS Opinion
=1.5mg/kg bw/dNOAELoralratSCCS Opinion
=3mg/kg bw/dayNOAELoralratSCCS Opinion
=3mg/kg bw/dNOAELoralratSCCS Opinion
=10mg/kg bw/dayNOAELoralratSCCS Opinion
=12mg/kg bw/dayNOAELoralratSCCS Opinion
=0.00032mg/kg bwdermal absorptionoralratRegulatory source
=1.5mg/kg bw/ddermal absorptionoralratRegulatory source
=3mg/kg bw/ddermal absorptionoralratRegulatory source
12mg/kg bw/daydevelopmental toxicityoralratRegulatory source
3mg/kg bw/daygenotoxicity--Regulatory source
3mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
10mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
3mg/kg bw/dayreproductive toxicity-ratRegulatory source

Showing 14 of 14 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1542/1416 March 2016safe0.5%strong skin sensitiser; tertiary amine; nitrosamine <50ppb

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.5%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1)?

Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) has 14 NOAEL studies in the database. The lowest reported value is 0.00032 mg/kg bw via oral in rat. Source: SCCS Opinion.

What regulatory lists include Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1)?

Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) used in cosmetics?

Yes, Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) is also indexed as a cosmetic ingredient under the name Basic Blue 124. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) used outside industrial chemicals?

Phenoxazin-5-ium, 3-amino-7-(dimethylamino)-2-methoxy-, chloride (1:1) also appears in cosmetics databases.