Is Basic Blue 124 safe in cosmetics?
Basic Blue 124 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Basic Blue 124
INCI: BASIC BLUE 124
Basic Blue 124 (CAS 67846-56-4) is a cosmetic cosmetic ingredient functioning as Hair dyeing (cationic direct dye for semi-permanent formulations). Reported NOAEL =0.00032 mg/kg bw in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: permitted, max 0.5%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 67846-56-4 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing (cationic direct dye for semi-permanent formulations)
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
Hair dye products exempt from color additive certification under FD&C Act coal-tar hair dye exemption (21 USC 361(a)), provided label bears caution statement
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Basic Blue 124.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Basic Blue 124. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.00032 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.00032 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.00032 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.00032 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =1.5 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =1.5 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =1.5 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =1.5 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =3 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =3 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: As from 3 September 2017: 0,5 %.
BRIN Brazil/India Cosmetics
India: Restricted · max As from 3 September 2017: 0,5 %
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 5.0% | - | - | SCCS/0179 |
| measured | 0.0003% | - | - | SCCS/0179 |
| measured | 0.0004% | - | - | SCCS/0179 |
| measured | 0.008% | - | - | SCCS/0179 |
| measured | 0.0005% | - | - | SCCS/0179 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "67846-56-4", "ingredient_class": "direct_dye", "chemical_class": "other", "color_result_on_hair": "Blue", "shade_range": "fashion_color", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "8-15", "light_fastness": "moderate", "oxidation_mechanism": "direct_absorption", "hair_penetration…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Basic Blue 124.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Basic Blue 124 by CAS number or substance name.
Studies
24
Lowest NOAEL
0.00032
Highest NOAEL
12
Units vary across source rows: mg/kg bw, mg/kg bw/d, mg/kg bw/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 5.0% | - | - |
| 0.0003% | - | - |
| 0.0004% | - | - |
| 0.008% | - | - |
| 0.0005% | - | - |
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Frequently Asked Questions
Is Basic Blue 124 allowed in the EU?
Basic Blue 124 EU regulatory status: permitted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Basic Blue 124 do in cosmetics?
Basic Blue 124 functions as: Hair dyeing (cationic direct dye for semi-permanent formulations). It is classified as a cosmetic ingredient in our database. CAS number: 67846-56-4.
What is the NOAEL for Basic Blue 124?
The NOAEL (No Observed Adverse Effect Level) for Basic Blue 124 is =0.00032 mg/kg bw based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Compliance Tools
Check Basic Blue 124 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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