What is the NOAEL for Retinol?
Retinol has 26 NOAEL studies in the database. The lowest reported value is 49.27 uM. Source: NTP ICE endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Retinol
Also known as: All-trans retinol, Vitamin A, Retinol, all-trans-, 4-06-00-04133, Axerophtholum (+15 more)
CAS 68-26-8
Retinol (CAS 68-26-8) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Retinol is classified GHS Danger (H302, H317, H319, H360, H413) in the chemicals database but is restricted in EU cosmetics at max 0.05% RE in body lotions; 0.3% RE in other leave-on and rinse-off products.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
26
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
Retinol
CAS Number
68-26-8
Molecular Formula
C20H30O
InChI Key
FPIPGXGPPPQFEQ-OVSJKPMPSA-N
Monoisotopic Mass
286.229666
Synonyms
All-trans retinolVitamin ARetinol, all-trans-4-06-00-04133AxerophtholumBRN 04030403,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-EINECS 200-683-7Homagenets AoralRetrovitamin ASehkraft A
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Softener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 26 of 26 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 58.24 | uM | AC50 | - | - | NTP ICE endocrine |
| 49.27 | uM | ACC | - | - | NTP ICE endocrine |
| G2SH0XKK91 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >3000 | mg/day | LEL | oral | Human | EFSA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0564 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.48 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3.8 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 9 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 21 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 30 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 39 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS DB |
| 48 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 50 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 51 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 53 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 54 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 75 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 90 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 100 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 113 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 115 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 137 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 216 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 450 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
Showing 26 of 26 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Retinol | 200-683-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
0.05% RE in body lotions; 0.3% RE in other leave-on and rinse-off products
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
RETINOL
ChEMBL Phase
4
Adverse Events
1884
Bioactivity
22
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Retinol?
Retinol appears on 6 regulatory/inventory lists including pharmaceutical, Europe; supplements, Europe; food_additive; supplements, and 3 more. Source: EPA CPDat.
Is Retinol used in cosmetics?
Yes, Retinol is also indexed as a cosmetic ingredient under the name Retinol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Retinol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Retinol have different safety status in cosmetics vs industrial chemicals?
Retinol is classified GHS Danger (H302, H317, H319, H360, H413) in the chemicals database but is restricted in EU cosmetics at max 0.05% RE in body lotions; 0.3% RE in other leave-on and rinse-off products.
Is Retinol used outside industrial chemicals?
Retinol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.