What is the NOAEL for Basic Blue 99?
Basic Blue 99 has 21 NOAEL studies in the database. The lowest reported value is P0U7VBC51E UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Basic Blue 99
CAS 68123-13-7
Basic Blue 99 (CAS 68123-13-7) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Basic Blue 99 is prohibited in EU cosmetics but has active industrial GHS classifications (H318).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
Basic Blue 99
CAS Number
68123-13-7
DTXSID
DTXSID60874042
Molecular Formula
C19H19BrN4O2.ClH
InChI Key
RFQSMLBZXQOMKK-UHFFFAOYSA-N
Monoisotopic Mass
450.045816
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| - | International Journal of Toxicology | Published Articles |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| P0U7VBC51E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P0U7VBC51E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P0U7VBC51E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P0U7VBC51E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =62.8 | % | NOAEL | - | - | SCCS_vision_codex |
| =62.8 | % | NOAEL | - | - | SCCS_vision_codex |
| =62.8 | % | NOAEL | - | - | SCCS_vision_codex |
| =62.8 | % | NOAEL | - | - | SCCS_vision_codex |
| =74 | - | NOAEL | dermal | - | SCCS_vision_codex |
| =74 | - | NOAEL | dermal | - | SCCS_vision_codex |
| =74 | - | NOAEL | dermal | - | SCCS_vision_codex |
| =74 | - | NOAEL | dermal | - | SCCS_vision_codex |
| =200 | mg/kg | NOAEL | - | - | SCCS_vision_codex |
| =200 | mg/kg | NOAEL | - | - | SCCS_vision_codex |
| =200 | mg/kg | NOAEL | - | - | SCCS_vision_codex |
| =200 | mg/kg | NOAEL | - | - | SCCS_vision_codex |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=180 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <=360 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | ppm | NOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-[(4-amino-6-bromo-5,8-dihydro-1-hydroxy-8-imino-5-oxo-2-naphtyl)amino]-N,N,N-trimethylanilinium chloride | 268-544-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1683/25 | 2 February 2026 | not safe | - | genotoxicity potential; skin sensitiser; variable composition |
| SCCS/1585/17 | 6 June 2017 | insufficient data | - | highly variable composition between batches |
| SCCS/1537/14 | 23 September 2014 | insufficient data | - | highly variable composition (up to 40 substances) |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include Basic Blue 99?
Basic Blue 99 appears on 2 regulatory/inventory lists including children; Europe; Personal care, Europe; Personal care - hair coloring. Source: EPA CPDat.
Is Basic Blue 99 used in cosmetics?
Yes, Basic Blue 99 is also indexed as a cosmetic ingredient under the name Basic Blue 99. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Basic Blue 99 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Basic Blue 99 have different safety status in cosmetics vs industrial chemicals?
Basic Blue 99 is prohibited in EU cosmetics but has active industrial GHS classifications (H318).
Is Basic Blue 99 used outside industrial chemicals?
Basic Blue 99 also appears in cosmetics databases.