Basic Blue 99
INCI: BASIC BLUE 99
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Basic Blue 99. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 37 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
| NOAEL | 60 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 125.8 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
for which a TTC approach would be applicable. The SCCS considers a purity of only 80 % to be too low for the safety evaluation of a synthetic compound, particularly when the test material shows marked differences from the batches used in toxicological studies. SCCS/1683/25 Final version Scientific Advice on
Sensitization Profile
Contact sensitization data for Basic Blue 99 based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Composition variability is the primary concern with approximately 63% pure dye content and remainder sugars/salts containing potentially 40+ isomeric forms. Weak mutagen in some in vitro assays but CIR concluded no carcinogenic potential at hair dye use levels. Negative 90-day oral, negative DART, negative sensitization/irritation studies.
Regulatory Flags
Frequently Asked Questions
Is Basic Blue 99 safe in cosmetics?
Composition variability is the primary concern with approximately 63% pure dye content and remainder sugars/salts containing potentially 40+ isomeric forms. Weak mutagen in some in vitro assays but CIR concluded no carcinogenic potential at hair dye use levels. Negative 90-day oral, negative DART, negative sensitization/irritation studies. The EU classifies Basic Blue 99 as "prohibited". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs and cir.
Is Basic Blue 99 allowed in the EU?
Basic Blue 99 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Basic Blue 99 do in cosmetics?
Basic Blue 99 functions as: Hair colorant (naphthoquinoneimine dye), hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 68123-13-7.
What is the Margin of Safety for Basic Blue 99?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Basic Blue 99?
The NOAEL (No Observed Adverse Effect Level) for Basic Blue 99 is 37 mg/kg bw/day based on a toxicological study via oral route in rat. A total of 3 study endpoints are available. Source: SCCS_PDF_extraction.
Compliance Tools
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