INCI: BASIC BLUE 99
Basic Blue 99 (CAS 68123-13-7) is a cosmetic cosmetic ingredient functioning as Hair colorant (naphthoquinoneimine dye), hair conditioning agent. NOAEL 37 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; 2 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 68123-13-7 →
Basic Blue 99 is prohibited in EU cosmetics but has active industrial GHS classifications (H318).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Basic Blue 99.
Calculate MoS for your specific formulation with the MoS Calculator.
5 study endpoints found for Basic Blue 99. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =200 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =200 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =200 mg/kg | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =50 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
for which a TTC approach would be applicable. The SCCS considers a purity of only 80 % to be too low for the safety evaluation of a synthetic compound, particularly when the test material shows marked differences from the batches used in toxicological studies. SCCS/1683/25 Final version Scientific Advice on
Pre-calculated NOAEL → SED → MoS audit trail for Basic Blue 99 across SCCS product categories, with measured dermal absorption where available.
Contact sensitization data for Basic Blue 99 based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 3 | Non-oxidative hair dye (direct) |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 50.0 | method=measured | - | - |
3 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Basic Blue 99.
Public NOAEL study rows linked to Basic Blue 99 by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg
| Absorption % | Method | Vehicle |
|---|---|---|
| 50.0 | method=measured | - |
Basic Blue 99 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 5 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs and cir.
Basic Blue 99 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
Basic Blue 99 functions as: Hair colorant (naphthoquinoneimine dye), hair conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 68123-13-7.
The NOAEL (No Observed Adverse Effect Level) for Basic Blue 99 is =200 mg/kg based on a NOAEL study study via oral route in rat. A total of 5 study endpoints are available. Source: SCCS_vision_codex.
Basic Blue 99 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Basic Blue 99 is prohibited in EU cosmetics but has active industrial GHS classifications (H318).
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