What is the NOAEL for 2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol?
2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol has 11 NOAEL studies in the database. The lowest reported value is 7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol
Also known as: 1-Butanol, 2,2-bis[(2-propenyloxy)methyl]-, 2,2-Bis((2-propenyloxy)methyl)-1-butanol, BRN 1934010, 1-Butanol, 2,2-di((2-propenyloxy)methyl)-, EINECS 211-661-1 (+1 more)
CAS 682-09-7
2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol (CAS 682-09-7) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Trimethylolpropane Diallyl Ether →
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol
CAS Number
682-09-7
DTXSID
DTXSID7044976
Molecular Formula
C12H22O3
InChI Key
BDKDHWOPFRTWPP-UHFFFAOYSA-N
Monoisotopic Mass
214.156895
Synonyms
1-Butanol, 2,2-bis[(2-propenyloxy)methyl]-2,2-Bis((2-propenyloxy)methyl)-1-butanolBRN 19340101-Butanol, 2,2-di((2-propenyloxy)methyl)-EINECS 211-661-1UNII-Q58WDK0444
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| Q58WDK0444 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q58WDK0444 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q58WDK0444 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q58WDK0444 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =800 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =800 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2-bis(allyloxymethyl)butan-1-ol | 211-661-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184580
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol used in cosmetics?
Yes, 2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol is also indexed as a cosmetic ingredient under the name Trimethylolpropane Diallyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol used outside industrial chemicals?
2,2-Bis[(prop-2-en-1-yloxy)methyl]butan-1-ol also appears in cosmetics, pharmaceutical databases.