Is Trimethylolpropane Diallyl Ether safe in cosmetics?
Trimethylolpropane Diallyl Ether has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted. 2 toxicological study endpoint(s) are available in our database.
Trimethylolpropane Diallyl Ether
Also known as: 1-Butanol, 2,2-bis[(2-propenyloxy)methyl]-, 2,2-Bis((2-propenyloxy)methyl)-1-butanol, BRN 1934010, 1-Butanol, 2,2-di((2-propenyloxy)methyl)-, EINECS 211-661-1 (+1 more)
INCI: TRIMETHYLOLPROPANE DIALLYL ETHER
Trimethylolpropane Diallyl Ether (CAS 682-09-7) is a cosmetic cosmetic ingredient functioning as Solvent (cosmetic); primarily an industrial reactive diluent/crosslinker. Reported NOAEL =200 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 682-09-7 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent (cosmetic); primarily an industrial reactive diluent/crosslinker
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,2-bis(prop-2-enoxymethyl)butan-1-ol
InChIKey
BDKDHWOPFRTWPP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylolpropane Diallyl Ether.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Trimethylolpropane Diallyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =800 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Trimethylolpropane Diallyl Ether.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Trimethylolpropane Diallyl Ether by CAS number or substance name.
Studies
2
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
800 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1-Butanol, 2,2-bis[(2-propenyloxy)methyl]-
2,2-Bis((2-propenyloxy)methyl)-1-butanol
BRN 1934010
1-Butanol, 2,2-di((2-propenyloxy)methyl)-
EINECS 211-661-1
UNII-Q58WDK0444
Chemical Function
No specific technical function
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184580
Frequently Asked Questions
Is Trimethylolpropane Diallyl Ether allowed in the EU?
Trimethylolpropane Diallyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylolpropane Diallyl Ether do in cosmetics?
Trimethylolpropane Diallyl Ether functions as: Solvent (cosmetic); primarily an industrial reactive diluent/crosslinker. It is classified as a cosmetic ingredient in our database. CAS number: 682-09-7.
What is the NOAEL for Trimethylolpropane Diallyl Ether?
The NOAEL (No Observed Adverse Effect Level) for Trimethylolpropane Diallyl Ether is =200 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Trimethylolpropane Diallyl Ether used outside cosmetics?
Trimethylolpropane Diallyl Ether also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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