NOAEL Data REACH Registered Cosmetic Ingredient

N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride

Also known as: 3-((4,5-Dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo)-N,N,- N-trimethylbenzenaminium chloride, Basic yellow 57

CAS 68391-31-1

N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride (CAS 68391-31-1) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Basic Yellow 57 →

Cross-Vertical Regulatory Divergence

N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride is classified GHS CMR hazard (H361d) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields

Name

N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride

CAS Number

68391-31-1

DTXSID

DTXSID50275928

Molecular Formula

C19H22N5O.ClH

InChI Key

NWKBFCIAPOSTKG-ANVLNOONSA-M

Monoisotopic Mass

372.159113

Synonyms

3-((4,5-Dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo)-N,N,- N-trimethylbenzenaminium chlorideBasic yellow 57

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
4N63359G0X	UNII	FDA UNII substance identifier	-	-	openFDA substances
4N63359G0X	UNII	FDA UNII substance identifier	-	-	openFDA substances
4N63359G0X	UNII	FDA UNII substance identifier	-	-	openFDA substances
4N63359G0X	UNII	FDA UNII substance identifier	-	-	openFDA substances
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=20	mg/kg	NOAEL	dermal	-	SCCNFP_vision_codex
=20	mg/kg	NOAEL	dermal	-	SCCNFP_vision_codex
=20	mg/kg	NOAEL	dermal	-	SCCNFP_vision_codex
=20	mg/kg	NOAEL	dermal	-	SCCNFP_vision_codex
=50	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=50	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=50	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=50	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
50	mg/kg bw/day	irritation	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
20	mg/kg	repeated dose toxicity	dermal	-	UnifiedCodex:SCCNFP:beta.noael_studies

Showing 15 of 15 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-N,N,N-trimethylanilinium chloride	269-943-5	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1395/10	23 March 2010	safe	2.0%	sensitisation potential; secondary amine; nitrosamine <50ppb

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Frequently Asked Questions

What is the NOAEL for N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride?

N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride has 15 NOAEL studies in the database. The lowest reported value is 4N63359G0X UNII. Source: openFDA substances.

What regulatory lists include N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride?

N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride appears on 4 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), children; Europe; Personal care, Europe; Personal care - hair coloring, and 1 more. Source: EPA CPDat.

Is N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride used in cosmetics?

Yes, N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride is also indexed as a cosmetic ingredient under the name Basic Yellow 57. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride have different safety status in cosmetics vs industrial chemicals?

Is N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride used outside industrial chemicals?

N,N,N-trimethyl-3-[(E)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1h-pyrazol-4-yl)diazenyl]anilinium chloride also appears in cosmetics databases.