Also known as: 3-((4,5-Dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo)-N,N,- N-trimethylbenzenaminium chloride
INCI: BASIC YELLOW 57
Basic Yellow 57 (CAS 68391-31-1) is a cosmetic cosmetic ingredient functioning as Hair dyeing (semi-permanent cationic dye). Reported NOAEL =20 mg/kg (SCCNFP_vision_codex); EU Regulation 1223/2009 status: restricted; 5 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 68391-31-1 →
Basic Yellow 57 is classified GHS CMR hazard (H361d) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Basic Yellow 57.
Calculate MoS for your specific formulation with the MoS Calculator.
8 study endpoints found for Basic Yellow 57. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =20 mg/kg | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =20 mg/kg | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =20 mg/kg | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =20 mg/kg | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | oral | rat | irritation | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | oral | rat | irritation | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | oral | rat | irritation | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | oral | rat | irritation | SCCNFP_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
data to determine the safety of this ingredient. The Panel concluded that Basic Yellow 57 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safet
data to determine the safety of this ingredient. The Panel concluded that Basic Yellow 57 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safet
data to determine the safety of this ingredient. The Panel concluded that Basic Yellow 57 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safet
data to determine the safety of this ingredient. The Panel concluded that Basic Yellow 57 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safet
data to determine the safety of this ingredient. The Panel concluded that Basic Yellow 57 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safet
Contact sensitization data for Basic Yellow 57 based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 2 | Non-oxidative hair dye (direct) |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 7.87% | - | - | 2010-03-23 |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Basic Yellow 57.
Public NOAEL study rows linked to Basic Yellow 57 by CAS number or substance name.
Units vary across source rows: mg/kg, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 7.87% | SCCS opinion extraction | - |
Basic Yellow 57 has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 8 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Basic Yellow 57 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
Basic Yellow 57 functions as: Hair dyeing (semi-permanent cationic dye). It is classified as a cosmetic ingredient in our database. CAS number: 68391-31-1.
The NOAEL (No Observed Adverse Effect Level) for Basic Yellow 57 is =20 mg/kg based on a repeated dose toxicity study via dermal route in rat. A total of 8 study endpoints are available. Source: SCCNFP_vision_codex.
Basic Yellow 57 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Basic Yellow 57 is classified GHS CMR hazard (H361d) in the chemicals database but is restricted in EU cosmetics.
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