What is the NOAEL for Gamma-Caprolactone?
Gamma-Caprolactone has 13 NOAEL studies in the database. The lowest reported value is 8.82 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Gamma-Caprolactone
Also known as: 5-Ethyldihydrofuran-2(3H)-one, 2(3H)-Furanone, 5-ethyldihydro-, 5-17-09-00040, BRN 0107260, EINECS 211-778-8 (+15 more)
CAS 695-06-7
Gamma-Caprolactone (CAS 695-06-7) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Gamma-Caprolactone
CAS Number
695-06-7
DTXSID
DTXSID8041298
Molecular Formula
C6H10O2
InChI Key
JBFHTYHTHYHCDJ-UHFFFAOYSA-N
Monoisotopic Mass
114.06808
Synonyms
5-Ethyldihydrofuran-2(3H)-one2(3H)-Furanone, 5-ethyldihydro-5-17-09-00040BRN 0107260EINECS 211-778-84-Ethyl-4-butanolide4-Ethyl-4-hydroxybutanoic acid lactoneFEMA No. 2556Hexanoic acid, 4-hydroxy-, gamma-lactonegamma-HexanolactoneNSC 134769NSC 24255
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
DeodorizerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =8.82 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| J16NAT1G41 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J16NAT1G41 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J16NAT1G41 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J16NAT1G41 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexan-4-olide | 211-778-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL192458
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Gamma-Caprolactone?
Gamma-Caprolactone appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, artificial_saliva; detected; emissions; Europe; Toys and children's products, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is Gamma-Caprolactone used in cosmetics?
Yes, Gamma-Caprolactone is also indexed as a cosmetic ingredient under the name Gamma-Caprolactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Gamma-Caprolactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Gamma-Caprolactone used outside industrial chemicals?
Gamma-Caprolactone also appears in cosmetics, pharmaceutical, cannabis databases.