What is the GHS hazard classification for 1-Propanol?
1-Propanol (CAS 71-23-8) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; Eye Dam. 1 with signal word Danger. Hazard statements: H225; H336; H318. Source: EU CLP Annex VI (ECHA).
Danger
GHS02GHS07GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Propanol
Also known as: n-propanol, 4-01-00-01413, Albacol, Alcohol, propyl, BRN 1098242 (+15 more)
CAS 71-23-8
1-Propanol (CAS 71-23-8) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H336; H318. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
1-Propanol is classified GHS Danger (H225, H336, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
15
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
1-Propanol
CAS Number
71-23-8
DTXSID
DTXSID2021739
Molecular Formula
C3H8O
InChI Key
BDERNNFJNOPAEC-UHFFFAOYSA-N
Monoisotopic Mass
60.057515
Synonyms
n-propanol4-01-00-01413AlbacolAlcohol, propylBRN 1098242Caswell No. 709AEINECS 200-746-9EPA Pesticide Chemical Code 047502FEMA No. 2928FEMA Number 29281-Propyl alcoholPropyl alcohol, normal
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; STOT SE 3; Eye Dam. 1 | H225; H336; H318 | GHS02; GHS07; GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Causes serious eye damage May cause drowsiness or dizziness May be harmful if swallowed and enters airways |
| Short-term Effects | The substance is severely irritating to the eyes. The substance may cause effects on the central nervous system. Exposure at high levels could cause unconsciousness. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, by ingestion and through the skin. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
7 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 200 ppm (500 mg/m³) | 200 | 500 | N |
| NIOSH | TWA | 200 ppm (500 mg/m³) | 200 | 500 | Y |
| NIOSH | STEL | 250 ppm (625 mg/m³) | 250 | 625 | Y |
| ACGIH | TWA | 100 ppm [2006] | 100 | - | N |
| CAL/OSHA | TWA | 200 ppm (500 mg/m³) | 200 | 500 | Y |
| CAL/OSHA | STEL | 250 ppm (625 mg/m³) | 250 | 625 | Y |
| NIOSH | IDLH | 800 ppm | 800 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
17 records
SolventDefoamerFlavouring and nutrientFragranceWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
15 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; emissions; Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =268 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 96F264O9SV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 96F264O9SV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 96F264O9SV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 96F264O9SV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| >26.76 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >33.8 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >51.91 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >62.48 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =54074.4 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =6054 | ppm | LOEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc102 |
| =6054 | ppm | LOEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc102 |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 604 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =893 | mg/m3 | NOEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc102 |
| =893 | mg/m3 | NOEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc102 |
| =3659 | ppm | NOEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc102 |
| =3659 | ppm | NOEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc102 |
| 5 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propan-1-ol | 200-746-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PROPANOL
ChEMBL Phase
-1
Adverse Events
2
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for 1-Propanol?
1-Propanol has 21 NOAEL studies in the database. The lowest reported value is 268 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include 1-Propanol?
1-Propanol appears on 14 regulatory/inventory lists including inert_ingredient; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, and 11 more. Source: EPA CPDat.
What are the occupational exposure limits for 1-Propanol?
Occupational exposure limits for 1-Propanol are set by OSHA, NIOSH, ACGIH. 7 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 1-Propanol used in cosmetics?
Yes, 1-Propanol is also indexed as a cosmetic ingredient under the name Propyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Propanol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Propanol have different safety status in cosmetics vs industrial chemicals?
1-Propanol is classified GHS Danger (H225, H336, H318) in the chemicals database but is allowed in EU cosmetics.
Is 1-Propanol used outside industrial chemicals?
1-Propanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.