Good Cosmetic Ingredient NOAEL Data GHS Classified

Propyl Alcohol

INCI: PROPYL ALCOHOL

CAS Number

71-23-8

Function

Antifoaming agent, Solvent

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Permitted; CIR concluded safe for use in cosmetic formulations in present practices

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

moderate

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Propyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	500 mg/kg bw/day	oral	rat	Special Toxicology Study	COSMOS_DB
NOAEL	604 mg/kg bw/day	oral	rat	Special Toxicology Study	COSMOS_DB
dose_tested	500 mg/kg bw/day	oral	rat	Special Toxicology Study	COSMOS_DB
LOAEL	32 other	oral	rat	oral	REACH
LOAEL	32 other	oral	rat	oral	REACH
LOAEL	0.8 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	>4000 mg/kg bw/day	oral	mouse	oral	REACH
NOAEL	>0.003 mg/kg bw/day	oral	rat	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; corr; excl mark;warn

Hazard Statements

Highly flammable liquid and vapour Causes serious eye damage May cause drowsiness or dizziness May be harmful if swallowed and enters airways

Short-term Exposure Effects

The substance is severely irritating to the eyes. The substance may cause effects on the central nervous system. Exposure at high levels could cause unconsciousness. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis.

Long-term Exposure Effects

The substance defats the skin, which may cause dryness or cracking.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour, by ingestion and through the skin.

Expert Verdict

CNS depressant at high systemic doses; flammable; synthetic origin

⚠️

Concern Level: Low

Regulatory Flags

ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Propyl Alcohol safe in cosmetics?

CNS depressant at high systemic doses; flammable; synthetic origin The EU classifies Propyl Alcohol as "permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is Propyl Alcohol allowed in the EU?

Propyl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propyl Alcohol do in cosmetics?

Propyl Alcohol functions as: Antifoaming agent, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 71-23-8.

What is the Margin of Safety for Propyl Alcohol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Propyl Alcohol?

The NOAEL (No Observed Adverse Effect Level) for Propyl Alcohol is 500 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Is Propyl Alcohol classified as hazardous under GHS?

Propyl Alcohol carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Causes serious eye damage May cause drowsiness or dizziness May be harmful if swallowed and enters airways. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Propyl Alcohol compliance across multiple jurisdictions:

🔬

Ingredient Decoder

Paste a full ingredient list for instant analysis

🌸

82 Allergen Checker

Check for EU declarable fragrance allergens

🧪

Substance Compliance

Check compliance across 55 jurisdictions

🧮

MoS Calculator

Calculate Margin of Safety using SCCS methodology

⚗️

Heavy Metal Limits

Compare limits across jurisdictions

Related Ingredients

2-Ethylhexylal

Good

PEG/PPG-23/17 Copolymer

Good

Butoxyethanol

Moderate

Perfluorodimethylcyclohexane

Moderate

Epsilon-Caprolactone

Moderate

Browse all 30,000+ ingredients →

📱

Is Propyl Alcohol in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Propyl Alcohol in your formulation.

Ingredient Decoder MoS Calculator