NOAEL Data REACH Registered Cosmetic Ingredient

(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

Also known as: HEPES, 5-23-02-00379, BRN 0883043, EINECS 230-907-9, N-2-Hydroxyethylpiperazine N',2'-ethanesulfonic acid (+7 more)

CAS 7365-45-9

(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid (CAS 7365-45-9) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

CAS Number

7365-45-9

DTXSID

DTXSID5040382

Molecular Formula

C8H18N2O4S

InChI Key

JKMHFZQWWAIEOD-UHFFFAOYSA-N

Monoisotopic Mass

238.098728

Synonyms

HEPES5-23-02-00379BRN 0883043EINECS 230-907-9N-2-Hydroxyethylpiperazine N',2'-ethanesulfonic acidN-2-Hydroxyethylpiperazine-N-ethane sulfonic acid4-(2-Hydroxyethyl)-1-piperazineethane sulfonic acidN-2-Hydroxyethylpiperazine-N'-ethanesulfonateN-2-Hydroxyethylpiperazine-N'-ethanesulfonic acidUNII-RWW266YE9I2-[4-(2-hydroxyethyl)-2,3,5,6-tetrahydropyrazin-1-yl]ethanesulfonate2-[4-(2-hydroxyethyl)piperazin-4-ium-1-yl]ethanesulfonate

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

pH regulating agent

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 7 of 7 studies

Value	Unit	Endpoint	Route	Species	Source
=23.5	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
RWW266YE9I	UNII	FDA UNII substance identifier	-	-	openFDA substances
RWW266YE9I	UNII	FDA UNII substance identifier	-	-	openFDA substances
RWW266YE9I	UNII	FDA UNII substance identifier	-	-	openFDA substances
RWW266YE9I	UNII	FDA UNII substance identifier	-	-	openFDA substances
>2000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1000	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 7 of 7 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4-(2-hydroxyethyl)piperazin-1-ylethanesulphonic acid	230-907-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1232545

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for (4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid?

(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid has 7 NOAEL studies in the database. The lowest reported value is 23.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

Is (4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid used in cosmetics?

Yes, (4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid is also indexed as a cosmetic ingredient under the name Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is (4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid used outside industrial chemicals?

(4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid also appears in cosmetics, pharmaceutical databases.