Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES)

CAS Number
7365-45-9
Function
pH regulating agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no FDA restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

HEPES can generate free radicals in the presence of oxygen and transition metals with potential pro-oxidant effects in formulation; eye irritation risk if product contacts eyes; no established safe concentration protocol for cosmetics specifically.

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Concern Level: Moderate

Frequently Asked Questions

Is Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) safe in cosmetics?

HEPES can generate free radicals in the presence of oxygen and transition metals with potential pro-oxidant effects in formulation; eye irritation risk if product contacts eyes; no established safe concentration protocol for cosmetics specifically. The EU classifies Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) as "permitted". Safety rating: MODERATE.

Is Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) allowed in the EU?

Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) do in cosmetics?

Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) functions as: pH regulating agent. It is classified as a cosmetic ingredient in our database. CAS number: 7365-45-9.

What is the Margin of Safety for Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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