Danger GHS02GHS04GHS08 NOAEL Data IARC Group 1 Prop 65 REACH Registered Cosmetic Ingredient

Vinyl chloride

Also known as: Ethene, chloro-, EC No.: 200-831-0, 4-01-00-00700, BRN 1731576, Chlorethene (+15 more)

CAS 75-01-4

Vinyl chloride (CAS 75-01-4) is a chemical substance with GHS signal word Danger; key hazard signal: H220; H350. Key regulatory status: California Proposition 65, REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Vinyl Chloride →

Cross-Vertical Regulatory Divergence

Vinyl chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H350).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Vinyl chloride

CAS Number

75-01-4

DTXSID

DTXSID8021434

Molecular Formula

C2H3Cl

InChI Key

BZHJMEDXRYGGRV-UHFFFAOYSA-N

Monoisotopic Mass

61.992328

Synonyms

Ethene, chloro-EC No.: 200-831-04-01-00-00700BRN 1731576ChloretheneChlorethyleneEINECS 200-831-0RCRA waste number U043TrovidurVinyl chlorineVinylchlorideCloruro di vinile

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 1	Carcinogenic to humans	2009	Sup 7, 97, 100F

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Gas 1; Press. Gas; Carc. 1A	H220; H350	GHS02; GHS04; GHS08	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Extremely flammable gas Contains gas under pressure; may explode if heated May cause drowsiness or dizziness May cause damage to liver through prolonged or repeated exposure Suspected of causing genetic defects May cause cancer
Short-term Effects	The liquid may cause frostbite. The substance is irritating to the eyes. The substance may cause effects on the central nervous system. This may result in lowering of consciousness, convulsions and seizures. Medical observation is indicated.
Long-term Effects	The substance may have effects on the liver, spleen, blood, peripheral blood vessels and tissue and bones of the fingers. Animal tests show that this substance possibly causes toxicity to human reproduction or development. This substance is carcinogenic to humans.
Routes of Exposure	The substance can be absorbed into the body by inhalation.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	1 ppm [0.5 ppm Action Level]	1	-	N
OSHA	CEILING	5 ppm [15 minutes]	5	-	N
CAL/OSHA	TWA	1 ppm	1	-	Y
AIHA	ERPG-1	500 ppm	500	-	-
AIHA	ERPG-2	5000 ppm	5000	-	-
AIHA	ERPG-3	20000 ppm	20000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Degradant/impurityMonomers

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 18 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
Cons electronics mech appliances and machinery; Europe	Danish Environmental Protection Agency	Danish EPA
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington
Arts and crafts/Office supplies - children's art and toys - modeling clay; Europe; nondetect	Danish Environmental Protection Agency	Danish EPA
children	Vermont Department of Health	State of Vermont
children	Maine Department of Environmental Protection	State of Maine
Europe; Food contact items; Toys and children's products	Danish EPA	Danish EPA
Europe; Food contact items; Toys and children's products	Danish EPA	Danish EPA
detected; Europe; Food contact items; Toys and children's products	Danish EPA	Danish EPA
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
children	Oregon Health Authority	State of Oregon
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 91 studies

Value	Unit	Endpoint	Route	Species	Source
=5.24031	mg/m3	BMCL (10)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=6.953	mg/m3	BMCL (10)	inhalation	Rat	ToxValDB_TX_TCEQ
=1.27813	mg/m3	BMCL (HEC)	inhalation	Rat	ToxValDB_ATSDR_MRLs
LC3	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
LC3	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
LC3	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
LC3	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
LCcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
147.3	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
147.3	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
WD06X94M2D	UNII	FDA UNII substance identifier	-	-	openFDA substances
WD06X94M2D	UNII	FDA UNII substance identifier	-	-	openFDA substances
WD06X94M2D	UNII	FDA UNII substance identifier	-	-	openFDA substances
WD06X94M2D	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.4183	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
0.5924	fraction	Fu	-	Human	NTP_ICE_adme_parameters
1	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
1	unitless	IARC group	-	-	NTP_ICE_cancer
0.0000044	ug/m3	Inhalation risk unit	Inhalation	-	NTP_ICE_cancer
0.0000088	ug/m3	Inhalation risk unit	Inhalation	-	NTP_ICE_cancer
383.1971	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
390	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
459.8365	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=97137.5	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
>=255625	mg/m3	LEL	inhalation	Guinea Pig	ToxValDB_ECHA_IUCLID
=127.812	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=12781.2	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=51125	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=127812	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1.3	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_IRIS
=1.7	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_DOE_Wildlife_Benchmarks
=1.7	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=25.3	mg/m3	LOAEL (HEC)	oral	Rat	ToxValDB_IRIS
=0.9	mg/kg bw/day	LOAEL (HED)	oral	Rat	ToxValDB_IRIS
=260	mg/m3	LOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=25	ppm	LOEL	oral	Mouse	ToxValDB_ECOTOX
=0.051125	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=1.27813	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=25.5625	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=127.812	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=255.625	mg/m3	NOAEC	inhalation	Rabbit	ToxValDB_ECHA_IUCLID
=511.25	mg/m3	NOAEC	inhalation	Dog	ToxValDB_ECHA_IUCLID
=2811.88	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=0.09	mg/kg/day	NOAEL	oral	Rat (Wistar; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.13	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.13	mg/kg bw	NOAEL	-	Rat	INCHEM_WHO_hsg_hsg_hsg109

Showing 50 of 91 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Chloroethylene	200-831-0	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Vinyl chloride	-	-

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL VINYL CHLORIDE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Vinyl chloride?

Vinyl chloride (CAS 75-01-4) is classified under EU CLP Annex VI as Flam. Gas 1; Press. Gas; Carc. 1A with signal word Danger. Hazard statements: H220; H350. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Vinyl chloride?

Vinyl chloride has 91 NOAEL studies in the database. The lowest reported value is 0.0000088 ug/m3 via Inhalation. Source: NTP_ICE_cancer.

What regulatory lists include Vinyl chloride?

Vinyl chloride appears on 14 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, Cons electronics mech appliances and machinery; Europe, and 11 more. Source: EPA CPDat.

Is Vinyl chloride a carcinogen according to IARC?

Vinyl chloride is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Vinyl chloride on the California Proposition 65 list?

Yes, Vinyl chloride is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Vinyl chloride?

Occupational exposure limits for Vinyl chloride are set by OSHA, CAL/OSHA, AIHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Vinyl chloride used in cosmetics?

Yes, Vinyl chloride is also indexed as a cosmetic ingredient under the name Vinyl Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Vinyl chloride come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Does Vinyl chloride have different safety status in cosmetics vs industrial chemicals?

Vinyl chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H350).

Is Vinyl chloride used outside industrial chemicals?

Vinyl chloride also appears in cosmetics, pharmaceutical, food safety databases.