Is Vinyl Chloride safe in cosmetics?
Vinyl Chloride has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited. 2 toxicological study endpoint(s) are available in our database.
Vinyl Chloride
Also known as: Ethene, chloro-, EC No.: 200-831-0, 4-01-00-00700, BRN 1731576, Chlorethene (+15 more)
INCI: VINYL CHLORIDE
Vinyl Chloride (CAS 75-01-4) is a cosmetic cosmetic ingredient functioning as Insufficient Data. Reported NOAEL =13 mg/kg bw (INCHEM_WHO_ehc_ehc_ehc215); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 75-01-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Vinyl Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H280, H341, H350, H412).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Insufficient Data
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
No specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Vinyl Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Vinyl Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =13 mg/kg bw | - | - | Toxicology study | INCHEM_WHO_ehc_ehc_ehc215 |
| NOAEL | =30 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameCylinderGasExcl markWarnCancerHealth haz
Hazard Statements
Extremely flammable gas Contains gas under pressure; may explode if heated May cause drowsiness or dizziness May cause damage to liver through prolonged or repeated exposure Suspected of causing genetic defects May cause cancer
Short-term Exposure Effects
The liquid may cause frostbite. The substance is irritating to the eyes. The substance may cause effects on the central nervous system. This may result in lowering of consciousness, convulsions and seizures. Medical observation is indicated.
Long-term Exposure Effects
The substance may have effects on the liver, spleen, blood, peripheral blood vessels and tissue and bones of the fingers. Animal tests show that this substance possibly causes toxicity to human reproduction or development. This substance is carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
1
Volume
Sup 7, 97, 100F
Evaluation Year
2009
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableCompressed GasHealth Hazard
Hazard Class and Category
Flam. Gas 1; Press. Gas; Carc. 1A
Hazard Statements
- H220 Extremely flammable gas
- H350 May cause cancer
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000,000 - 10,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 334
(EC) 2009/1223
CMR: Carcinogenic Cat. 1A()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
JPKR Japan/Korea Cosmetics
Japan (Prohibited): Must not be used
Korea (Prohibited): ; Category: General
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (5)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | banned | - | All cosmetics |
| IN | banned | - | all cosmetics including aerosols |
| AU | banned | - | all |
| CA | banned | - | - |
| ASEAN | banned | - | All cosmetic products prohibited |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Degradant/impurity
Monomers
No specific technical function
Regulatory List Membership (4)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Vinyl Chloride.
Regulatory Flags
EU Restricted
CMR
prop65
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Vinyl Chloride by CAS number or substance name.
Studies
2
Lowest NOAEL
13
Highest NOAEL
30
Units vary across source rows: mg/kg bw/day, mg/kg bw
ToxValDB_ECHA_IUCLID
INCHEM_WHO_ehc_ehc_ehc215
Known Synonyms
Ethene, chloro-
EC No.: 200-831-0
4-01-00-00700
BRN 1731576
Chlorethene
Chlorethylene
EINECS 200-831-0
RCRA waste number U043
Trovidur
Vinyl chlorine
Vinylchloride
Cloruro di vinile
Vinyle(chlorure de)
Winylu chlorek
UNII-WD06X94M2D
VC
chlorure de vinyle
ethylene monochloride
monochloroethene
monovinyl chloride
Chemical Function
Degradant/impurity
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
drinking_water; Europe; manufacturing; plastic_additive
Cons electronics mech appliances and machinery; Europe
Indirect additives food contact (10/2018)
OEHHA Proposition 65 (3/2019)
Australia; Food and drug - smoking-related products
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
children; WA Children's Safe Product Act (4/2020)
Arts and crafts/Office supplies - children's art and toys - modeling clay; Europe; nondetect
children
children
Europe; Food contact items; Toys and children's products
Europe; Food contact items; Toys and children's products
detected; Europe; Food contact items; Toys and children's products
OEHHA Proposition 65 (1/2023)
children
banned; Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
VINYL CHLORIDE
ChEMBL ID
CHEMBL2311071
Max Phase
4
Frequently Asked Questions
Is Vinyl Chloride allowed in the EU?
Vinyl Chloride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Vinyl Chloride do in cosmetics?
Vinyl Chloride functions as: Insufficient Data. It is classified as a cosmetic ingredient in our database. CAS number: 75-01-4.
What is the NOAEL for Vinyl Chloride?
The NOAEL (No Observed Adverse Effect Level) for Vinyl Chloride is =13 mg/kg bw based on a Toxicology study study via oral route in rat. A total of 2 study endpoints are available. Source: INCHEM_WHO_ehc_ehc_ehc215.
Is Vinyl Chloride classified as hazardous under GHS?
Vinyl Chloride carries a GHS signal word of "DANGER". Hazard statements: Extremely flammable gas Contains gas under pressure; may explode if heated May cause drowsiness or dizziness May cause damage to liver through prolonged or repeated exposure Suspected of causing genetic defects May cause cancer. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Vinyl Chloride used outside cosmetics?
Vinyl Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Vinyl Chloride have different safety status in cosmetics vs industrial chemicals?
Vinyl Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H280, H341, H350, H412).
Compliance Tools
Check Vinyl Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ACETALDEHYDE
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Chemical family
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Chlorofluorocarbons (CFCs)
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Chemical family
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DICHLOROMETHANE
Moderate
Chemical family
Perfuming, Solvent
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