Also known as: Ethanal, Acetic ethanol, Acetylaldehyde, EINECS 200-836-8, FEMA No. 2003 (+8 more)
CAS 75-07-0
Acetaldehyde (CAS 75-07-0) is a chemical substance with GHS signal word Danger; key hazard signal: H224; H350; H341; H335; H319. Key regulatory status: California Proposition 65, REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Acetaldehyde is classified GHS Danger (H224, H350, H341, H335, H319) in the chemicals database but is restricted in EU cosmetics at max II/1391.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 1 | Carcinogenic to humans | 2009 | 100E |
| Group 2B | Possibly carcinogenic | 1998 | 36, Sup 7, 71 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 1; Carc. 1B; Muta. 2; STOT SE 3; Eye Irrit. 2 | H224; H350; H341; H335; H319 | GHS02; GHS08; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the respiratory tract. This may result in tissue lesions. This substance is possibly carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 200 ppm (360 mg/m³) | 200 | 360 | N |
| CAL/OSHA | CEILING | 25 ppm (45 mg/m³) | 25 | 45 | N |
| NIOSH | IDLH | 2000 ppm | 2000 | - | - |
| AIHA | ERPG-1 | 10 ppm | 10 | - | - |
| AIHA | ERPG-2 | 200 ppm | 200 | - | - |
| AIHA | ERPG-3 | 1000 ppm | 1000 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| consumer_product; detected | Elsevier | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; Batteries; Cons electronics mech appliances and machinery; emissions; Europe; Other direct contact consumer goods; Other indirect contact consumer goods; Toys and children's products | Ministry of Environment and Food of Denmark; Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; Batteries; emissions; Europe; nondetect | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5 | ppm | - | inhalation | rat | Regulatory source |
| 400 | ppm | - | inhalation | rat | Regulatory source |
| 500 | mg/kg bw/day | - | - | rat | Regulatory source |
| =178 | mg/m3 | BMC (05) | inhalation | Rat | ToxValDB Cal OEHHA REL derivations |
| SQEinhalation=90 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| GO1N1ZPR3B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP ICE cancer |
| 0.0000022 | ug/m3 | Inhalation risk unit | Inhalation | - | NTP ICE cancer |
| 23.95 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 24 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 25 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 37 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 37.31 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =661 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1930 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =125 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| =675 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| =7.207e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =142 | mg/m3 | LOAEL | inhalation | Human | ToxValDB Cal OEHHA REL derivations |
| 675 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =728 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB IRIS |
| =130 | mg/m3 | LOAEL (ADJ) | inhalation | Rat | ToxValDB IRIS |
| =16.9 | mg/m3 | LOAEL (HEC) | inhalation | Rat | ToxValDB IRIS |
| =50 | mg/100 mL | LOEL | environmental | Mouse | ToxValDB ECOTOX |
| =675 | mg/kg bw | LOEL | - | - | WHO/JECFA |
| =0.5 | mg/kg bw/d | NOAEL | dermal | rat | SCCS Opinion |
| =5 | ppm | NOAEL | inhalation | rat | SCCS Opinion |
| 10 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS DB |
| =120 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =120 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =125 | mg/kg bw/d | NOAEL | inhalation | - | SCCS Opinion |
| =150 | ppm | NOAEL | oral | rat | SCCS Opinion |
| 240 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =273 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB IRIS |
| 324 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =400 | ppm | NOAEL | inhalation | rat | SCCS Opinion |
| =500 | mg/kg bw/day | NOAEL | - | rat | SCCS Opinion |
| 675 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =6000 | ppm | NOAEL | oral | Rat | ECHA |
| =1.200e+4 | ppm | NOAEL | oral | Rat | ECHA |
| =48.75 | mg/m3 | NOAEL (ADJ) | inhalation | Rat | ToxValDB IRIS |
| =8.7 | mg/m3 | NOAEL (HEC) | inhalation | Rat | ToxValDB IRIS |
| =8.7 | mg/m^3 | NOAEL (HEC) | inhalation | - | Regulatory source |
| =10 | mg/100 mL | NOEL | environmental | Mouse | ToxValDB ECOTOX |
| =125 | mg/kg bw/day | NOEL | oral | Rat | EFSA |
Showing 50 of 61 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Acetaldehyde | 200-836-8 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Acetaldehyde | - | - |
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1474/12 | 18 September 2012 | not safe | Not safe in cosmetic products | Carcinogen (IARC Group 1); mutagenic; reproductive toxicity; irritant |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Acetaldehyde (CAS 75-07-0) is classified under EU CLP Annex VI as Flam. Liq. 1; Carc. 1B; Muta. 2; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H224; H350; H341; H335; H319. Source: EU CLP Annex VI (ECHA).
Acetaldehyde has 61 NOAEL studies in the database. The lowest reported value is 0.0000022 ug/m3 via Inhalation. Source: NTP ICE cancer.
Acetaldehyde appears on 30 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Cons electronics mech appliances and machinery; detected; emissions; Europe, and 27 more. Source: EPA CPDat.
Acetaldehyde is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Acetaldehyde is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Occupational exposure limits for Acetaldehyde are set by OSHA, CAL/OSHA, NIOSH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Acetaldehyde is also indexed as a cosmetic ingredient under the name ACETALDEHYDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Acetaldehyde is classified GHS Danger (H224, H350, H341, H335, H319) in the chemicals database but is restricted in EU cosmetics at max II/1391.
Acetaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.