Moderate Cosmetic Ingredient NOAEL Data GHS Classified

ACETALDEHYDE

CAS Number
75-07-0
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. II/1391
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
NOAEL: No oral mg/kg bw/day NOAEL; inhalation NOAEL(ADJ) 48.75 mg/m³ (rat, 6 h/day, 5 d/week) | Source: US EPA IRIS summary for acetaldehyde (CASRN 75‑07‑0) (1991)

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for ACETALDEHYDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10 mg/kg bw/day oral guinea pig Subchronic COSMOS_DB
NOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 675 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 400 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 240 mg/kg bw/day oral rat Reproductive COSMOS_DB
NOAEL 324 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 125 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 125 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
LOAEL 675 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 400 mg/kg bw/day oral rat Developmental COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the respiratory tract. This may result in tissue lesions. This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Expert Verdict

ACETALDEHYDE is listed in the EU CosIng database with functions: Fragrance It is restricted under EU Cosmetics Regulation. Restriction: II/1391.

⚠️
Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted fragrance needs-enrichment endocrine_disruptor prop65 eu_banned_cosmetics ifra_fragrance fda_food_additive eu_cosing_listed jecfa_safe

Frequently Asked Questions

Is ACETALDEHYDE safe in cosmetics?

ACETALDEHYDE is listed in the EU CosIng database with functions: Fragrance It is restricted under EU Cosmetics Regulation. Restriction: II/1391. The EU classifies ACETALDEHYDE as "Restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is ACETALDEHYDE allowed in the EU?

ACETALDEHYDE EU regulatory status: Restricted. Maximum allowed concentration: II/1391. This is based on EU Regulation 1223/2009 and its amendments.

What does ACETALDEHYDE do in cosmetics?

ACETALDEHYDE functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 75-07-0.

What is the Margin of Safety for ACETALDEHYDE?

NOAEL: No oral mg/kg bw/day NOAEL; inhalation NOAEL(ADJ) 48.75 mg/m³ (rat, 6 h/day, 5 d/week) | Source: US EPA IRIS summary for acetaldehyde (CASRN 75‑07‑0) (1991) The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for ACETALDEHYDE?

The NOAEL (No Observed Adverse Effect Level) for ACETALDEHYDE is 10 mg/kg bw/day based on a Subchronic study via oral route in guinea pig. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check ACETALDEHYDE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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