What is the NOAEL for Dimethyl sulfide?
Dimethyl sulfide has 63 NOAEL studies in the database. The lowest reported value is 12.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dimethyl sulfide
Also known as: Methane, thiobis-, 4-01-00-01275, BRN 1696847, EINECS 200-846-2, Exact-S (+15 more)
CAS 75-18-3
Dimethyl sulfide (CAS 75-18-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Dimethyl sulfide is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H301, H315, H318, H319, H335, H303, H316).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
63
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
26 fields
Name
Dimethyl sulfide
CAS Number
75-18-3
DTXSID
DTXSID9026398
Molecular Formula
C2H6S
InChI Key
QMMFVYPAHWMCMS-UHFFFAOYSA-N
Monoisotopic Mass
62.019021
Synonyms
Methane, thiobis-4-01-00-01275BRN 1696847EINECS 200-846-2Exact-SFEMA No. 2746Methyl sulphideMethyl thioetherDimethylsulphideSulfure de methyleUNII-QS3J7O7L3U(methylsulfanyl)methane
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
4 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 10 ppm [2001] | 10 | - | N |
| AIHA | ERPG-1 | 0.5 ppm | 0.5 | - | - |
| AIHA | ERPG-2 | 1000 ppm | 1000 | - | - |
| AIHA | ERPG-3 | 5000 ppm | 5000 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 63 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =12.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| QS3J7O7L3U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QS3J7O7L3U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QS3J7O7L3U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QS3J7O7L3U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 102.2158 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =3300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =55904.6 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| 15 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >=250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =250 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =0.06 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.06 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.2 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.2 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.23 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.23 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.43 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.43 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.44 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.44 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.52 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.52 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.56 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.56 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.7 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =0.7 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =1.2 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =1.2 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =1.4 | mg/kg bw | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =1.4 | mg/kg bw | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =1.9 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =1.9 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =2.8 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =2.8 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =3.1 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =3.1 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =3.4 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =3.4 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =4.6 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =4.6 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =4.8 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =4.8 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =6.5 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =6.5 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
| =7 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v44jec09 |
Showing 50 of 63 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethyl sulphide | 200-846-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
METHYLSULFANYLMETHANE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dimethyl sulfide?
Dimethyl sulfide appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, consumer_product, and 1 more. Source: EPA CPDat.
What are the occupational exposure limits for Dimethyl sulfide?
Occupational exposure limits for Dimethyl sulfide are set by ACGIH, AIHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Dimethyl sulfide used in cosmetics?
Yes, Dimethyl sulfide is also indexed as a cosmetic ingredient under the name Dimethyl Sulphide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethyl sulfide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Dimethyl sulfide have different safety status in cosmetics vs industrial chemicals?
Dimethyl sulfide is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H301, H315, H318, H319, H335, H303, H316).
Is Dimethyl sulfide used outside industrial chemicals?
Dimethyl sulfide also appears in cosmetics, pharmaceutical, cannabis databases.