Is Dimethyl Sulphide safe in cosmetics?
Dimethyl Sulphide has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dimethyl Sulphide
Also known as: Methane, thiobis-, 4-01-00-01275, BRN 1696847, EINECS 200-846-2, Exact-S (+15 more)
INCI: DIMETHYL SULPHIDE
Dimethyl Sulphide (CAS 75-18-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (masking). NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Dimethyl Sulphide is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H301, H315, H318, H319, H335, H303, H316).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Fragrance ingredient (masking)
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
methylsulfanylmethane
InChIKey
QMMFVYPAHWMCMS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — FEMA GRAS; no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyl Sulphide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Sulphide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dimethyl Sulphide across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0878
Source: WHO/JECFA
Skin Eye Respiratory Irritation
... Causes softening and irritation of the skin. Orally it is an irritant. Inhalation can cause dizziness and unconsciousness. | Dimethyl sulfide is a slight skin irritant ...
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (4)
JECFA Number
452
Source: WHO/JECFA
JECFA Evaluation
2-THIAPROPANE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: WHO/JECFA
JECFA Evaluation
METHYL SULFIDE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: WHO/JECFA
JECFA Evaluation
THIOBISMETHANE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Dimethyl Sulphide — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dimethyl Sulphide by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
COSMOS DB
Known Synonyms
Methane, thiobis-
4-01-00-01275
BRN 1696847
EINECS 200-846-2
Exact-S
FEMA No. 2746
Methyl sulphide
Methyl thioether
Dimethylsulphide
Sulfure de methyle
UNII-QS3J7O7L3U
(methylsulfanyl)methane
2-Thiopropane
DMS
Dimethyl sulfide (natural)
Dimethyl sulfide [UN1164] [Flammable liquid]
Dimethyl sulfoxide(Reduced)
Dimethyl thioether
MSM
Methanethiomethane
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
consumer_product
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
METHYLSULFANYLMETHANE
ChEMBL ID
CHEMBL15580
Frequently Asked Questions
Is Dimethyl Sulphide allowed in the EU?
Dimethyl Sulphide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Sulphide do in cosmetics?
Dimethyl Sulphide functions as: Fragrance ingredient (masking). It is classified as a cosmetic ingredient in our database. CAS number: 75-18-3.
What is the NOAEL for Dimethyl Sulphide?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Sulphide is 300 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. Source: COSMOS DB.
Is Dimethyl Sulphide used outside cosmetics?
Dimethyl Sulphide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethyl Sulphide have different safety status in cosmetics vs industrial chemicals?
Dimethyl Sulphide is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H301, H315, H318, H319, H335, H303, H316).
Compliance Tools
Check Dimethyl Sulphide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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