Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Dimethyl Sulphide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 15 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 15 mg/kg bw/day | oral | rabbit | Chronic | COSMOS_DB |
| dose_tested | 15 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | >=250 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Strong unpleasant odor at low thresholds (~0.02 ppm); flammable with flash point −36 °C; significant handling and storage safety considerations required; aquatic screening assessment needed.
Regulatory Flags
Frequently Asked Questions
Is Dimethyl Sulphide safe in cosmetics?
Strong unpleasant odor at low thresholds (~0.02 ppm); flammable with flash point −36 °C; significant handling and storage safety considerations required; aquatic screening assessment needed. The EU classifies Dimethyl Sulphide as "prohibited". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Dimethyl Sulphide allowed in the EU?
Dimethyl Sulphide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Sulphide do in cosmetics?
Dimethyl Sulphide functions as: Fragrance ingredient (masking). It is classified as a cosmetic ingredient in our database. CAS number: 75-18-3.
What is the Margin of Safety for Dimethyl Sulphide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Sulphide?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Sulphide is 300 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Dimethyl Sulphide compliance across multiple jurisdictions:
Related Ingredients
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