What is the NOAEL for Vinylidene fluoride?
Vinylidene fluoride has 10 NOAEL studies in the database. The lowest reported value is 1045 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Vinylidene fluoride
Also known as: Ethene, 1,1-difluoro-, EINECS 200-867-7, Halocarbon 1132A, NCI-C60204, NCI-C60208 (+5 more)
CAS 75-38-7
Vinylidene fluoride (CAS 75-38-7) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Vinylidene fluoride is classified GHS Danger (H220, H230, H280, H340, H350, H336) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Vinylidene fluoride
CAS Number
75-38-7
DTXSID
DTXSID3021439
Molecular Formula
C2H2F2
InChI Key
BQCIDUSAKPWEOX-UHFFFAOYSA-N
Monoisotopic Mass
64.012456
Synonyms
Ethene, 1,1-difluoro-EINECS 200-867-7Halocarbon 1132ANCI-C60204NCI-C60208UNII-3C1IX2905BHFC-1132aVF2C2H2F2CF2=CH2
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 39, Sup 7, 71 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the central nervous system. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
4 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 1 ppm | 1 | - | N |
| NIOSH | CEILING | 5 ppm [15 minutes] | 5 | - | N |
| ACGIH | TWA | 500 ppm [1996] | 500 | - | N |
| CAL/OSHA | TWA | 100 ppm (262 mg/m³) | 100 | 262 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1045 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3C1IX2905B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3C1IX2905B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3C1IX2905B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3C1IX2905B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >65.4347 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 240 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =144047 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,1-difluoroethylene | 200-867-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL116020
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Vinylidene fluoride?
Vinylidene fluoride appears on 2 regulatory/inventory lists including Indirect additives food contact (10/2018), drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.
Is Vinylidene fluoride a carcinogen according to IARC?
Vinylidene fluoride is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Vinylidene fluoride?
Occupational exposure limits for Vinylidene fluoride are set by NIOSH, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Vinylidene fluoride used in cosmetics?
Yes, Vinylidene fluoride is also indexed as a cosmetic ingredient under the name Vinylidene Difluoride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Vinylidene fluoride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Vinylidene fluoride have different safety status in cosmetics vs industrial chemicals?
Vinylidene fluoride is classified GHS Danger (H220, H230, H280, H340, H350, H336) in the chemicals database but is allowed in EU cosmetics.
Is Vinylidene fluoride used outside industrial chemicals?
Vinylidene fluoride also appears in cosmetics, pharmaceutical databases.