What is the NOAEL for Chlorodifluoromethane?
Chlorodifluoromethane has 20 NOAEL studies in the database. The lowest reported value is ZFO627O6CN UNII. Source: openFDA substances.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Chlorodifluoromethane
Also known as: Methane, chlorodifluoro-, HCFC-22, Algofrene type 6, BRN 1731036, EINECS 200-871-9 (+3 more)
CAS 75-45-6
Chlorodifluoromethane (CAS 75-45-6) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
View cosmetic safety profile for Hydrochlorofluorocarbon 22 (HCFC-22) →
Cross-Vertical Regulatory Divergence
Chlorodifluoromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H280, H420, H316, H320, H336, H360, H361, H370).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
20
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Chlorodifluoromethane
CAS Number
75-45-6
DTXSID
DTXSID6020301
Molecular Formula
CHClF2
InChI Key
VOPWNXZWBYDODV-UHFFFAOYSA-N
Monoisotopic Mass
85.973484
Synonyms
Methane, chlorodifluoro-HCFC-22Algofrene type 6BRN 1731036EINECS 200-871-9Fluorocarbon-22Forane 22 BUNII-ZFO627O6CN
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 41, Sup 7, 71 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system and central nervous system. This may result in cardiac disorders and central nervous system depression. Exposure could cause lowering of consciousness. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
4 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 1000 ppm (3500 mg/m³) | 1000 | 3500 | N |
| NIOSH | STEL | 1250 ppm (4375 mg/m³) | 1250 | 4375 | N |
| ACGIH | TWA | 1000 ppm [1990] | 1000 | - | N |
| CAL/OSHA | TWA | 1000 ppm (3500 mg/m³) | 1000 | 3500 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
RefrigerantsSealant (barrier)FoamantIntermediatePropellants, non-motive (blowing agents)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ZFO627O6CN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZFO627O6CN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZFO627O6CN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZFO627O6CN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 1237.0418 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =176.831 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =176800 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_IRIS |
| =26300 | mg/m3 | LOAEL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =44200 | mg/m3 | LOAEL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =3537 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_IRIS |
| =35366.2 | mg/m3 | NOAEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =35366.2 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_EU_SCOEL |
| =35370 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_IRIS |
| =909 | mg/m3 | NOAEL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =5260 | mg/m3 | NOAEL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =5260 | mg/m^3 | NOAEL (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =50 | mg/m3 | RfC | inhalation | Human | ToxValDB_IRIS |
| =50 | mg/m^3 | RfC | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Chlorodifluoromethane | 200-871-9 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Chlorodifluoromethane (HCFC-22) | - | - |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL116155
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Chlorodifluoromethane?
Chlorodifluoromethane appears on 2 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, detected; drinking_water; MN Chemical Screening. Source: EPA CPDat.
Is Chlorodifluoromethane a carcinogen according to IARC?
Chlorodifluoromethane is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Chlorodifluoromethane?
Occupational exposure limits for Chlorodifluoromethane are set by NIOSH, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Chlorodifluoromethane used in cosmetics?
Yes, Chlorodifluoromethane is also indexed as a cosmetic ingredient under the name Hydrochlorofluorocarbon 22 (HCFC-22). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Chlorodifluoromethane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Chlorodifluoromethane have different safety status in cosmetics vs industrial chemicals?
Chlorodifluoromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H280, H420, H316, H320, H336, H360, H361, H370).
Is Chlorodifluoromethane used outside industrial chemicals?
Chlorodifluoromethane also appears in cosmetics, pharmaceutical databases.