Poor Cosmetic Ingredient GHS Classified

Hydrochlorofluorocarbon 22 (HCFC-22)

INCI: HYDROCHLOROFLUOROCARBON 22

CAS Number
75-45-6
Function
Propellant / refrigerant
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Phased out under Montreal Protocol and EPA Clean Air Act regulations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system and central nervous system. This may result in cardiac disorders and central nervous system depression. Exposure could cause lowering of consciousness. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation.

Expert Verdict

ODS with high global warming potential and cardiac sensitization risk at high inhalation exposure. Banned in all cosmetic applications globally.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Hydrochlorofluorocarbon 22 (HCFC-22) safe in cosmetics?

ODS with high global warming potential and cardiac sensitization risk at high inhalation exposure. Banned in all cosmetic applications globally. The EU classifies Hydrochlorofluorocarbon 22 (HCFC-22) as "prohibited". Safety rating: POOR.

Is Hydrochlorofluorocarbon 22 (HCFC-22) allowed in the EU?

Hydrochlorofluorocarbon 22 (HCFC-22) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydrochlorofluorocarbon 22 (HCFC-22) do in cosmetics?

Hydrochlorofluorocarbon 22 (HCFC-22) functions as: Propellant / refrigerant. It is classified as a cosmetic ingredient in our database. CAS number: 75-45-6.

What is the Margin of Safety for Hydrochlorofluorocarbon 22 (HCFC-22)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Hydrochlorofluorocarbon 22 (HCFC-22) compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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Is Hydrochlorofluorocarbon 22 (HCFC-22) in Your Products?

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Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydrochlorofluorocarbon 22 (HCFC-22) in your formulation.

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