Is Hydrochlorofluorocarbon 22 (HCFC-22) safe in cosmetics?
Hydrochlorofluorocarbon 22 (HCFC-22) has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Hydrochlorofluorocarbon 22 (HCFC-22)
Also known as: Methane, chlorodifluoro-, HCFC-22, Algofrene type 6, BRN 1731036, EINECS 200-871-9 (+3 more)
INCI: HYDROCHLOROFLUOROCARBON 22
Hydrochlorofluorocarbon 22 (HCFC-22) (CAS 75-45-6) is a cosmetic cosmetic ingredient functioning as Propellant / refrigerant. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 75-45-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hydrochlorofluorocarbon 22 (HCFC-22) is prohibited in EU cosmetics but has active industrial GHS classifications (H280, H420, H316, H320, H336, H360, H361, H370).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Propellant / refrigerant
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
chloro(difluoro)methane
InChIKey
VOPWNXZWBYDODV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Phased out under Montreal Protocol and EPA Clean Air Act regulations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydrochlorofluorocarbon 22 (HCFC-22).
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system and central nervous system. This may result in cardiac disorders and central nervous system depression. Exposure could cause lowering of consciousness. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
41, Sup 7, 71
Evaluation Year
1998
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Chlorodifluoromethane | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 41: (1986) Some Halogenated Hydrocarbons and Pesticide Exposures | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen P
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of chlorodifluoromethane. There is limited evidence in experimental animals for the carcinogenicity of chlorodifluoromethane. Overall evaluation: Chlorodifluoromethane is not classifiable as to its carcinogenicity in humans (Group 3). | A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0049
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Vapor not irritating to eyes, nose, or throat.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Foamant
Intermediate
Propellants
non-motive (blowing agents)
Refrigerants
Sealant (barrier)
Expert Verdict
Expert safety assessment and concern-level summary for Hydrochlorofluorocarbon 22 (HCFC-22).
Regulatory Flags
potential-allergen
Known Synonyms
Methane, chlorodifluoro-
HCFC-22
Algofrene type 6
BRN 1731036
EINECS 200-871-9
Fluorocarbon-22
Forane 22 B
UNII-ZFO627O6CN
Chemical Function
Refrigerants
Sealant (barrier)
Foamant
Intermediate
Propellants
non-motive (blowing agents)
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL116155
Frequently Asked Questions
Is Hydrochlorofluorocarbon 22 (HCFC-22) allowed in the EU?
Hydrochlorofluorocarbon 22 (HCFC-22) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrochlorofluorocarbon 22 (HCFC-22) do in cosmetics?
Hydrochlorofluorocarbon 22 (HCFC-22) functions as: Propellant / refrigerant. It is classified as a cosmetic ingredient in our database. CAS number: 75-45-6.
Is Hydrochlorofluorocarbon 22 (HCFC-22) used outside cosmetics?
Hydrochlorofluorocarbon 22 (HCFC-22) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hydrochlorofluorocarbon 22 (HCFC-22) have different safety status in cosmetics vs industrial chemicals?
Hydrochlorofluorocarbon 22 (HCFC-22) is prohibited in EU cosmetics but has active industrial GHS classifications (H280, H420, H316, H320, H336, H360, H361, H370).
Compliance Tools
Check Hydrochlorofluorocarbon 22 (HCFC-22) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ACETALDEHYDE
Moderate
Chemical family
Fragrance
Chlorofluorocarbons (CFCs)
Poor
Chemical family
aerosol propellants
DICHLOROMETHANE
Moderate
Chemical family
Perfuming, Solvent
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