What is the GHS hazard classification for Nitromethane?
Nitromethane (CAS 75-52-5) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 * with signal word Warning. Hazard statements: H226; H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS02GHS07
NOAEL Data
IARC Group 2B
Prop 65
REACH Registered
Cosmetic Ingredient
Nitromethane
Also known as: EINECS 200-876-6, Nitrometan, UNII-RU5WG8C3F4, CH3NO2, MeNO2
CAS 75-52-5
Nitromethane (CAS 75-52-5) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H302. Key regulatory status: California Proposition 65, REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
SOURCE
noael studies public
NOAEL studies
28
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Nitromethane
CAS Number
75-52-5
DTXSID
DTXSID2020977
Molecular Formula
CH3NO2
InChI Key
LYGJENNIWJXYER-UHFFFAOYSA-N
Monoisotopic Mass
61.016378
Synonyms
EINECS 200-876-6NitrometanUNII-RU5WG8C3F4CH3NO2MeNO2
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2000 | 77 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Acute Tox. 4 * | H226; H302 | GHS02; GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in central nervous system depression. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the peripheral nervous system, kidneys and liver. This may result in impaired functions. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
4 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 100 ppm (250 mg/m³) | 100 | 250 | N |
| ACGIH | TWA | 20 ppm [1997] | 20 | - | N |
| CAL/OSHA | TWA | 2 ppm (5 mg/m³) | 2 | 5 | N |
| NIOSH | IDLH | 750 ppm | 750 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Corrosion inhibitor
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| Europe; Personal care; restricted | European Commission | CosIng |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 28 of 28 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.31 | mg/m3 | BMCL (10 HEC) | inhalation | Mouse | ToxValDB_PPRTV_(CPHEA) |
| =1.6 | mg/m3 | BMCL (10 HEC) | inhalation | Mouse | ToxValDB_PPRTV_(CPHEA) |
| AB39 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB39 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB39 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB39 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| =39 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =20 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| RU5WG8C3F4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RU5WG8C3F4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RU5WG8C3F4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RU5WG8C3F4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =940 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2995.84 | mg/m3 | LEL | inhalation | Rat | ToxValDB_EPA_TSCA_8e |
| =182247 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| 469.346421267894 | mg/m3/day | POLY-3 lowest dose | Inhalation | Mouse | NTP_ICE_cancer |
| 936.196319018405 | mg/m3/day | POLY-3 lowest dose | Inhalation | Mouse | NTP_ICE_cancer |
| 1872.39263803681 | mg/m3/day | POLY-3 lowest dose | Inhalation | Mouse | NTP_ICE_cancer |
| =0.004 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.005 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| 375 | ppm | Top dose | Inhalation | Rat | NTP_ICE_cancer |
| 750 | ppm | Top dose | Inhalation | Mouse | NTP_ICE_cancer |
Showing 28 of 28 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Nitromethane | 200-876-6 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Nitromethane | - | - |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
III/18
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
NITROMETHANE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What is the NOAEL for Nitromethane?
Nitromethane has 28 NOAEL studies in the database. The lowest reported value is 1.31 mg/m3 via inhalation in Mouse. Source: ToxValDB_PPRTV_(CPHEA).
What regulatory lists include Nitromethane?
Nitromethane appears on 4 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), Europe; Personal care; restricted, OEHHA Proposition 65 (1/2023), and 1 more. Source: EPA CPDat.
Is Nitromethane a carcinogen according to IARC?
Nitromethane is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2000). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Nitromethane on the California Proposition 65 list?
Yes, Nitromethane is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
What are the occupational exposure limits for Nitromethane?
Occupational exposure limits for Nitromethane are set by OSHA, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Nitromethane used in cosmetics?
Yes, Nitromethane is also indexed as a cosmetic ingredient under the name NITROMETHANE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Nitromethane come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Nitromethane used outside industrial chemicals?
Nitromethane also appears in cosmetics, pharmaceutical databases.