Is NITROMETHANE safe in cosmetics?
NITROMETHANE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: prohibited.
NITROMETHANE
Also known as: EINECS 200-876-6, Nitrometan, UNII-RU5WG8C3F4, CH3NO2, MeNO2
NITROMETHANE (CAS 75-52-5) is a cosmetic cosmetic ingredient functioning as Anticorrosive. EU Regulation 1223/2009 status: restricted, max III/18. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
NITROMETHANE is classified GHS Danger (H226, H302, H332, H351, H361d, H316, H319, H335) in the chemicals database but is restricted in EU cosmetics at max III/18.
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
Function
Anticorrosive
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
nitromethane
InChIKey
LYGJENNIWJXYER-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
III/18
US US Status
prohibited
US Notes
Not specifically listed as prohibited by FDA, but not used in cosmetics; would be considered an adulterant if the product is found unsafe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in central nervous system depression.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the peripheral nervous system, kidneys and liver. This may result in impaired functions.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
77
Evaluation Year
2000
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *
Hazard Statements
- H226 Flammable liquid and vapour
- H302 Harmful if swallowed
Specific Concentration Limits / M-factors
*
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Rust inhibitor. Max: 0.003.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.003
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
| BR | restricted | 0.3 | Corrosion inhibitor only |
| ASEAN | restricted | 0.3% | Rust inhibitor in aerosol products |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (7)
Carcinogen Classification
Nitromethane | Group 2B: Possibly carcinogenic to humans | Volume 77: (2000) Some Industrial Chemicals
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Fish Project (Nitromethane) | TR-528: Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies) (2005 ) | 02/18/04 | FISH (Medaka) | M = N F = N | Under the conditions of these waterborne studies,…
Source: NTP Technical Reports
Carcinogen Classification
Nitromethane | TR-461: Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies) (1997 ) | 12/05/95 | No Evidence | Clear Evidence | Clear Evidence | Clear Evidence | Under the conditions of these 2-year inhalation studies, there was no evidence of carcinogenic activity of nitromethane in male F344/N rats exposed to 94, 188,…
Source: NTP Technical Reports
Evidence for Carcinogenicity
A3; Confirmed animal carcinogen with unknown relevance to humans.
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Corrosion inhibitor
Regulatory List Membership (2)
California Proposition 65 (OEHHA)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for NITROMETHANE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
prop65
eu_cosing_listed
Known Synonyms
EINECS 200-876-6
Nitrometan
UNII-RU5WG8C3F4
CH3NO2
MeNO2
Chemical Function
Corrosion inhibitor
Regulatory Lists
OEHHA Proposition 65 (3/2019)
Europe; Personal care; restricted
OEHHA Proposition 65 (1/2023)
inert_ingredient; non_food_use; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NITROMETHANE
ChEMBL ID
CHEMBL276924
Frequently Asked Questions
Is NITROMETHANE allowed in the EU?
NITROMETHANE EU regulatory status: restricted. Maximum allowed concentration: III/18. This is based on EU Regulation 1223/2009 and its amendments.
What does NITROMETHANE do in cosmetics?
NITROMETHANE functions as: Anticorrosive. It is classified as a cosmetic ingredient in our database. CAS number: 75-52-5.
Is NITROMETHANE used outside cosmetics?
NITROMETHANE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does NITROMETHANE have different safety status in cosmetics vs industrial chemicals?
NITROMETHANE is classified GHS Danger (H226, H302, H332, H351, H361d, H316, H319, H335) in the chemicals database but is restricted in EU cosmetics at max III/18.
Compliance Tools
Check NITROMETHANE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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