Moderate Cosmetic Ingredient NOAEL Data GHS Classified

NITROMETHANE

CAS Number
75-52-5
Function
Anticorrosive
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. III/18
🇺🇸 US Status prohibited
US Notes Not specifically listed as prohibited by FDA, but not used in cosmetics; would be considered an adulterant if the product is found unsafe

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

2 study endpoints found for NITROMETHANE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 30 mg/kg bw/day oral rat oral REACH
LOAEL 0.1 other oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in central nervous system depression.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the peripheral nervous system, kidneys and liver. This may result in impaired functions.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Expert Verdict

NITROMETHANE is listed in the EU CosIng database with functions: Anticorrosive It is restricted under EU Cosmetics Regulation. Restriction: III/18.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment prop65 eu_cosing_listed

Frequently Asked Questions

Is NITROMETHANE safe in cosmetics?

NITROMETHANE is listed in the EU CosIng database with functions: Anticorrosive It is restricted under EU Cosmetics Regulation. Restriction: III/18. The EU classifies NITROMETHANE as "Restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is NITROMETHANE allowed in the EU?

NITROMETHANE EU regulatory status: Restricted. Maximum allowed concentration: III/18. This is based on EU Regulation 1223/2009 and its amendments.

What does NITROMETHANE do in cosmetics?

NITROMETHANE functions as: Anticorrosive. It is classified as a cosmetic ingredient in our database. CAS number: 75-52-5.

What is the NOAEL for NITROMETHANE?

The NOAEL (No Observed Adverse Effect Level) for NITROMETHANE is 30 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

Compliance Tools

Check NITROMETHANE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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