NOAEL Data REACH Registered Cosmetic Ingredient

Dichlorodifluoromethane

Also known as: Methane, dichlorodifluoro-, CFC-12, Caswell No. 304, EINECS 200-893-9, EPA Pesticide Chemical Code 000014 (+9 more)

CAS 75-71-8

Dichlorodifluoromethane (CAS 75-71-8) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Chlorofluorocarbons (CFCs) →

Cross-Vertical Regulatory Divergence

Dichlorodifluoromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H280).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

Dichlorodifluoromethane

CAS Number

75-71-8

DTXSID

DTXSID6020436

Molecular Formula

CCl2F2

InChI Key

PXBRQCKWGAHEHS-UHFFFAOYSA-N

Monoisotopic Mass

119.934512

Synonyms

Methane, dichlorodifluoro-CFC-12Caswell No. 304EINECS 200-893-9EPA Pesticide Chemical Code 000014Fluorocarbon-12Kaiser chemicals 12Propellant 12RCRA waste number U075Refrigerant 12Ucon 12/halocarbon 12Diclorodifluometano

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system and central nervous system. This may result in cardiac disorders and central nervous system depression. Exposure could cause lowering of consciousness. See Notes.
Routes of Exposure	The substance can be absorbed into the body by inhalation.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	1000 ppm (4950 mg/m³)	1000	4950	N
NIOSH	TWA	1000 ppm (4950 mg/m³)	1000	4950	N
ACGIH	TWA	1000 ppm [1979]	1000	-	N
CAL/OSHA	TWA	1000 ppm (4950 mg/m³)	1000	4950	N
CAL/OSHA	CEILING	6200 ppm	6200	-	N
NIOSH	IDLH	15000 ppm	15000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

RefrigerantsHeat transferring agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 42 of 42 studies

Value	Unit	Endpoint	Route	Species	Source
<=1.5	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
0.2524	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
1.369	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
=1657	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
OFM06SG1KO	UNII	FDA UNII substance identifier	-	-	openFDA substances
OFM06SG1KO	UNII	FDA UNII substance identifier	-	-	openFDA substances
OFM06SG1KO	UNII	FDA UNII substance identifier	-	-	openFDA substances
OFM06SG1KO	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.411	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
0.773	fraction	Fu	-	Human	NTP_ICE_adme_parameters
>1000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=150	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_MN_MDH_HHBW
=985	mg/m3	LOAEL (HEC)	inhalation	Guinea Pig	ToxValDB_PPRTV_(CPHEA)
~150	mg/kg bw/day	NOAEC	oral	Rat	ToxValDB_ECHA_IUCLID
>=24726.1	mg/m3	NOAEC	inhalation	Dog	ToxValDB_ECHA_IUCLID
>=49452.2	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>=989044	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=15	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_IRIS
=15	mg/kg/day	NOAEL	oral	-	EPA_IRIS_iris_rfd_systems.csv
75	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
82	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
150	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
170	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
>170	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=171	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>179	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
379	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
>=24726.1	mg/m3	NOEC	inhalation	Mouse	ToxValDB_ECHA_IUCLID
>=989044	mg/m3	NOEC	inhalation	Rabbit	ToxValDB_ECHA_IUCLID
>150	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.1	mg/m3	RfC	inhalation	Human	ToxValDB_Pennsylvania_DEP_ToxValues
=0.2	mg/m3	RfC	inhalation	Human	ToxValDB_Alaska_DEC
=0.2	mg/m3	RfC	inhalation	Human	ToxValDB_Alaska_DEC
=1	mg/m3	RfC (provisional)	inhalation	Human	ToxValDB_PPRTV_(CPHEA)
=0.046	mg/kg bw/day	RfD	dermal	Human	ToxValDB_Alaska_DEC
=0.046	mg/kg bw/day	RfD	dermal	Human	ToxValDB_Alaska_DEC
=0.0571	mg/kg bw/day	RfD	inhalation	Human	ToxValDB_Alaska_DEC
=0.0571	mg/kg bw/day	RfD	inhalation	Human	ToxValDB_Alaska_DEC
=0.2	mg/kg bw/day	RfD	oral	Human	ToxValDB_Alaska_DEC
=0.2	mg/kg bw/day	RfD	oral	Human	ToxValDB_Alaska_DEC
=0.2	mg/kg/day	RfD	oral	-	EPA_IRIS_iris_rfd_systems.csv
=0.05	mg/kg bw/day	RfD (provisional)	oral	Human	ToxValDB_PPRTV_(CPHEA)

Showing 42 of 42 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Dichlorodifluoromethane	200-893-9	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 2 records

Chemical	Category	Flags
Dichlorodifluoromethane (CFC-12)	-	-
Dichlorodifluoromethane (CFC-12)	-	-

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DICHLORODIFLUOROMETHANE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Dichlorodifluoromethane?

Dichlorodifluoromethane has 42 NOAEL studies in the database. The lowest reported value is 0.2524 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Dichlorodifluoromethane?

Dichlorodifluoromethane appears on 2 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), detected; drinking_water; MN Chemical Screening. Source: EPA CPDat.

What are the occupational exposure limits for Dichlorodifluoromethane?

Occupational exposure limits for Dichlorodifluoromethane are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Dichlorodifluoromethane used in cosmetics?

Yes, Dichlorodifluoromethane is also indexed as a cosmetic ingredient under the name Chlorofluorocarbons (CFCs). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dichlorodifluoromethane come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Dichlorodifluoromethane have different safety status in cosmetics vs industrial chemicals?

Dichlorodifluoromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H280).

Is Dichlorodifluoromethane used outside industrial chemicals?

Dichlorodifluoromethane also appears in cosmetics, pharmaceutical databases.