Chlorofluorocarbons (CFCs)
INCI: CHLOROFLUOROCARBONS
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Chlorofluorocarbons (CFCs). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 75 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 170 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 379 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 82 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 170 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| dose_tested | 75 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| dose_tested | 150 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| dose_tested | 170 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Chlorofluorocarbons are prohibited in cosmetics in both the EU and US due to ozone depletion potential and environmental harm.
Regulatory Flags
Frequently Asked Questions
Is Chlorofluorocarbons (CFCs) safe in cosmetics?
Chlorofluorocarbons are prohibited in cosmetics in both the EU and US due to ozone depletion potential and environmental harm. The EU classifies Chlorofluorocarbons (CFCs) as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.
Is Chlorofluorocarbons (CFCs) allowed in the EU?
Chlorofluorocarbons (CFCs) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Chlorofluorocarbons (CFCs) do in cosmetics?
Chlorofluorocarbons (CFCs) functions as: aerosol propellants. It is classified as a Cosmetic Ingredient in our database. CAS number: 75-71-8.
What is the Margin of Safety for Chlorofluorocarbons (CFCs)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Chlorofluorocarbons (CFCs)?
The NOAEL (No Observed Adverse Effect Level) for Chlorofluorocarbons (CFCs) is 75 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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