What is the NOAEL for Beta-Cyclodextrin?
Beta-Cyclodextrin has 31 NOAEL studies in the database. The lowest reported value is 5 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Beta-Cyclodextrin
Also known as: 2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv., B 100H, BW 7, BW 7 (polysaccharide), Stereoisomer of 5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol (+14 more)
CAS 7585-39-9
Beta-Cyclodextrin (CAS 7585-39-9) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
31
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Beta-Cyclodextrin
CAS Number
7585-39-9
DTXSID
DTXSID1020358
Molecular Formula
C42H70O35
InChI Key
WHGYBXFWUBPSRW-FOUAGVGXSA-N
Monoisotopic Mass
1134.369764
Synonyms
2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv.B 100HBW 7BW 7 (polysaccharide)Stereoisomer of 5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolDexipar β-100Dexy Pearl 100HP-β-CDKleptose STDVTS 270CYCLODEXTRIN, β-betadex
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
DeodorizerProcessing aids not otherwise specifiedFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 31 of 31 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| <=5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| JV039JZZ3A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JV039JZZ3A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JV039JZZ3A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JV039JZZ3A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =18800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1950 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | LOEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =25000 | ppm | LOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =225 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =466 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_EFSA |
| =466 | mg/kg bw/day | NOAEL | - | Dog | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =466 | mg/kg bw/day | NOAEL | - | Dog | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >=600 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =600 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =600 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =654 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =654 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =654 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >=675 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =975 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| >=4160 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| >=600 | mg/kg bw/day | NOEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >=675 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =10000 | ppm | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 31 of 31 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cycloheptapentylose | 231-493-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Polysaccharides
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BETADEX
ChEMBL Phase
3
Adverse Events
18
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E459 — ADI: 5 mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Beta-Cyclodextrin?
Beta-Cyclodextrin appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), pharmaceutical, and 1 more. Source: EPA CPDat.
Is Beta-Cyclodextrin used in cosmetics?
Yes, Beta-Cyclodextrin is also indexed as a cosmetic ingredient under the name Cyclodextrin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Beta-Cyclodextrin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Beta-Cyclodextrin used outside industrial chemicals?
Beta-Cyclodextrin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.