Is Cyclodextrin safe in cosmetics?
Cyclodextrin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Cyclodextrin
Also known as: 2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv., B 100H, BW 7, BW 7 (polysaccharide), Stereoisomer of 5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol (+14 more)
INCI: CYCLODEXTRIN
Cyclodextrin (CAS 7585-39-9) is a cosmetic cosmetic ingredient functioning as Absorbent, Carrier, Encapsulant, Solubilizer. Reported NOAEL =225 mg/kg bw/day in Mouse (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Absorbent, Carrier, Encapsulant, Solubilizer
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
InChIKey
WHGYBXFWUBPSRW-FOUAGVGXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as food substance. No specific FDA cosmetic restrictions. Listed on TSCA inventory.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclodextrin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Cyclodextrin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =225 mg/kg bw/day | oral | Mouse | chronic | ECHA |
| NOAEL | =400 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =975 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Dog | chronic | ECHA |
| NOAEL | =5000 mg/kg bw/day | oral | Rat | developmental | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Evaluation
CYCLODEXTRIN B | 1995 | 0-5 mg/kg bw | JECFA revised the previous temporary ADI (0-6 mg/kg bw) and allocated an ADI of 0-5 mg/kg bw for beta-cyclodextrin based on a NOEL of 1.25% in the diet (equal to 470 mg/kg bw/day) in a 1-year study in dogs and a safety factor of 100. | TRS 859-JECFA 44/28 | FAS 35-JECFA 44/257
Source: WHO/JECFA
JECFA Evaluation
beta-CYCLODEXTRIN | 1995 | 0-5 mg/kg bw | JECFA revised the previous temporary ADI (0-6 mg/kg bw) and allocated an ADI of 0-5 mg/kg bw for beta-cyclodextrin based on a NOEL of 1.25% in the diet (equal to 470 mg/kg bw/day) in a 1-year study in dogs and a safety factor of 100. | TRS 859-JECFA 44/28 | FAS 35-JECFA 44/257
Source: WHO/JECFA
JECFA Evaluation
beta-SCHARDINGER DEXTRIN | 1995 | 0-5 mg/kg bw | JECFA revised the previous temporary ADI (0-6 mg/kg bw) and allocated an ADI of 0-5 mg/kg bw for beta-cyclodextrin based on a NOEL of 1.25% in the diet (equal to 470 mg/kg bw/day) in a 1-year study in dogs and a safety factor of 100. | TRS 859-JECFA 44/28 | FAS 35-JECFA 44/257
Source: WHO/JECFA
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Processing aids not otherwise specified
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Cyclodextrin — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cir-cleared
gras
low-dermal-absorption
encapsulant
well-characterized
epa_safer_alternative
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cyclodextrin by CAS number or substance name.
Studies
5
Lowest NOAEL
225 mg/kg bw/day
Highest NOAEL
5000 mg/kg bw/day
ECHA
Known Synonyms
2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv.
B 100H
BW 7
BW 7 (polysaccharide)
Stereoisomer of 5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
Dexipar β-100
Dexy Pearl 100
HP-β-CD
Kleptose STD
VTS 270
CYCLODEXTRIN, β-
betadex
.beta.-Cyclodextrin
beta-Dextrin
Dextrin, beta-cyclo
EINECS 231-493-2
Schardinger beta-dextrin
beta-Cycloheptaamylose
UNII-JV039JZZ3A
Chemical Function
Deodorizer
Processing aids not otherwise specified
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BETADEX
ChEMBL ID
CHEMBL415690
Max Phase
3
Adverse Event Associations
18
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Beta-cyclodextrin
E Number
E459
ADI
5 mg/kg bw
FDA GRAS
FDA has no questions
GRN
74
Food Category
emulsifier
Use in baked goods prepared from dry mixes, breakfast cereal, chewing gum, gelatins and puddings, dry mix for soups, flavored coffee and tea, compressed candies, processed cheese products, flavored savory snacks and crackers, dry mix for beverages as a flavor...
View full food safety profile →Frequently Asked Questions
Is Cyclodextrin allowed in the EU?
Cyclodextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclodextrin do in cosmetics?
Cyclodextrin functions as: Absorbent, Carrier, Encapsulant, Solubilizer. It is classified as a cosmetic ingredient in our database. CAS number: 7585-39-9.
What is the NOAEL for Cyclodextrin?
The NOAEL (No Observed Adverse Effect Level) for Cyclodextrin is =225 mg/kg bw/day based on a chronic study via oral route in Mouse. A total of 5 study endpoints are available. Source: ECHA.
Is Cyclodextrin used outside cosmetics?
Cyclodextrin also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cyclodextrin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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