Danger GHS08GHS07 NOAEL Data SVHC REACH Registered Cosmetic Ingredient

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

Also known as: EINECS 278-355-8

CAS 75980-60-8

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (CAS 75980-60-8) is a chemical substance with GHS signal word Danger; key hazard signal: H360Fd; H317. Key regulatory status: SVHC Candidate List, REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ECHA SVHC.

View cosmetic safety profile for Trimethylbenzoyl Diphenylphosphine Oxide (TPO) →

SOURCE NOAEL studies
NOAEL studies
26
SOURCE Chemical inventory jurisdictions
Regulatory lists
1
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
CAS Number
75980-60-8
Molecular Formula
C22H21O2P
InChI Key
VFHVQBAGLAREND-UHFFFAOYSA-N
Monoisotopic Mass
348.127917
Synonyms
EINECS 278-355-8

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA 1 records
SubstanceReasonIncluded
diphenyl(2,4,6-trimethylbenzoyl)phosphine oxideToxic for reproduction (Article 57c)14-Jun-2023

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Repr. 1B; Skin Sens. 1BH360Fd; H317GHS08; GHS07Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 27 records
Softener and conditionerPhotosensitizersHardenerCatalyst

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies
ValueUnitEndpointRouteSpeciesSource
100mg/kg bw/day--ratRegulatory source
=0.822mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
B9EIM2D97XUNIIFDA UNII substance identifier--openFDA substances
>5000mg/kg bwLD50oralRatNTP ICE acute oral
=500mg/kg bw/dayLELoralRatToxValDB EPA TSCA 8e
=0.033mg/kg bw/dayNOAELoralratSCCS Opinion
=50mg/kg bw/dNOAELoralratCIR Safety Assessment
=50mg/kg bw/dayNOAELoralratSCCS Opinion
=60mg/kg bw/dNOAELoralratCIR Safety Assessment
=100mg/kg bw/dNOAELoralratCIR Safety Assessment
=100mg/kg bw/dayNOAEL-ratSCCS Opinion
=150mg/kg bw/dNOAELoralratCIR Safety Assessment
=200mg/kg bw/dNOAEL--CIR Safety Assessment
60mg/kg bw/ddevelopmental toxicityoralratRegulatory source
>100mg/kg bw/ddevelopmental toxicityoralrabbitRegulatory source
200mg/kg bw/ddevelopmental toxicity--Regulatory source
=0.033mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
50mg/kg bw/drepeated dose toxicityoralratRegulatory source
50mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
50%repeated dose toxicityoralratRegulatory source
50mg/kg bw/dayrepeated dose toxicityoralrabbitRegulatory source
50mg/kg bw/dayrepeated dose toxicityoralmouseRegulatory source
100mg/kg bw/drepeated dose toxicityoralratRegulatory source
100mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
100mg/kg bw/dayrepeated dose toxicityoralmouseRegulatory source
150mg/kg bw/drepeated dose toxicityoralratRegulatory source

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredDiphenyl(2,4,6-trimethylbenzoyl)phosphine oxide278-355-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1528/1427 March 2014safe with restrictionsSafe in UV-cured nail products at specific concentrationsPhotoinitiator; potential for residual monomer; sensitisation potential

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
5%
Category
Rheology Modifier
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL3561198
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide?

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (CAS 75980-60-8) is classified under EU CLP Annex VI as Repr. 1B; Skin Sens. 1B with signal word Danger. Hazard statements: H360Fd; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide?

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide has 26 NOAEL studies in the database. The lowest reported value is 0.822 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide?

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide a Substance of Very High Concern (SVHC)?

Yes, Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c). Source: ECHA SVHC Candidate List.

Is Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide used in cosmetics?

Yes, Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is also indexed as a cosmetic ingredient under the name Trimethylbenzoyl Diphenylphosphine Oxide (TPO). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide have different safety status in cosmetics vs industrial chemicals?

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is prohibited in EU cosmetics at max 5% but has active industrial GHS classifications (H360Fd, H317).

Is Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide used outside industrial chemicals?

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide also appears in cosmetics, pharmaceutical databases.