Also known as: EINECS 278-355-8
INCI: TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) (CAS 75980-60-8) is a cosmetic cosmetic ingredient functioning as Photoinitiator for UV-curable nail gel systems. NOAEL 75 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 75980-60-8 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylbenzoyl Diphenylphosphine Oxide (TPO).
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Trimethylbenzoyl Diphenylphosphine Oxide (TPO). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =60 mg/kg bw/d | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =100 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =100 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
Pre-calculated NOAEL → SED → MoS audit trail for Trimethylbenzoyl Diphenylphosphine Oxide (TPO) across SCCS product categories, with measured dermal absorption where available.
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: ATP21
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| AU | restricted | - | gel nail polish |
| SA | banned | - | All cosmetics (previously restricted to artificial nails at 5%) |
| SA | banned | - | Artificial nail products (previously restricted to 5%) |
| BR | banned | - | - |
| UK | restricted | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 10.0% | - | - | SCCS/0149 |
Expert safety assessment and concern-level summary for Trimethylbenzoyl Diphenylphosphine Oxide (TPO).
Public NOAEL study rows linked to Trimethylbenzoyl Diphenylphosphine Oxide (TPO) by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 10.0% | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) EU regulatory status: prohibited. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) functions as: Photoinitiator for UV-curable nail gel systems. It is classified as a cosmetic ingredient in our database. CAS number: 75980-60-8.
The NOAEL (No Observed Adverse Effect Level) for Trimethylbenzoyl Diphenylphosphine Oxide (TPO) is =50 mg/kg bw/d based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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