Trimethylbenzoyl Diphenylphosphine Oxide (TPO)
INCI: TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Trimethylbenzoyl Diphenylphosphine Oxide (TPO). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
🚫 EU BAN effective Sept 2025 ; CMR2 classification (reproductive toxicity — testicular atrophy at high oral doses in rats) ; moderate skin sensitizer; eye irritant; alternatives include TPO-L (CAS 270586-78-2) and BAPO (CAS 162881-26-7)
Regulatory Flags
Frequently Asked Questions
Is Trimethylbenzoyl Diphenylphosphine Oxide (TPO) safe in cosmetics?
🚫 EU BAN effective Sept 2025 ; CMR2 classification (reproductive toxicity — testicular atrophy at high oral doses in rats) ; moderate skin sensitizer; eye irritant; alternatives include TPO-L (CAS 270586-78-2) and BAPO (CAS 162881-26-7) The EU classifies Trimethylbenzoyl Diphenylphosphine Oxide (TPO) as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Trimethylbenzoyl Diphenylphosphine Oxide (TPO) allowed in the EU?
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) EU regulatory status: prohibited. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylbenzoyl Diphenylphosphine Oxide (TPO) do in cosmetics?
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) functions as: Photoinitiator for UV-curable nail gel systems. It is classified as a cosmetic ingredient in our database. CAS number: 75980-60-8.
What is the Margin of Safety for Trimethylbenzoyl Diphenylphosphine Oxide (TPO)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trimethylbenzoyl Diphenylphosphine Oxide (TPO)?
The NOAEL (No Observed Adverse Effect Level) for Trimethylbenzoyl Diphenylphosphine Oxide (TPO) is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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