What is the NOAEL for Silica?
Silica has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Silica
Also known as: Silicon dioxide, SiO2, Aerosil M-300, Aerosil bs-50, Aerosil-degussa, Amorphous silica dust (+15 more)
CAS 7631-86-9
Silica (CAS 7631-86-9) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 51 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
51
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Silica
CAS Number
7631-86-9
DTXSID
DTXSID1029677
Molecular Formula
O2Si
InChI Key
VYPSYNLAJGMNEJ-UHFFFAOYSA-N
Monoisotopic Mass
59.966756
Synonyms
Silicon dioxide, SiO2Aerosil M-300Aerosil bs-50Aerosil-degussaAmorphous silica dustCabosil N 5Cabosil st-1Cab-o-sil M-5Caswell No. 734AEINECS 231-545-4EPA Pesticide Chemical Code 072605Hydrophobic silica 2482
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1996 | Sup 7, 68 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
AbrasiveViscosity modifierFillerAbsorbentFlow promoterPharmaceutical disintegrantThickening agentOpaciferAnti-caking agentProcessing aids not otherwise specifiedDispersing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
51 records
| List | Keyword | Source |
|---|---|---|
| Pesticides | National Park Service | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| - | Journal of Chemical Engineering & Process Technology | Published Articles |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 5 | % | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 5 | % | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 500 | mg/kg | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 500 | mg/kg | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =2.12 | (mg/m3 )-yr CDE | BMCL (01) | inhalation | Human | ToxValDB_Cal_OEHHA_REL_derivations |
| 2.7 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| ETJ7Z6XBU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ETJ7Z6XBU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ETJ7Z6XBU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ETJ7Z6XBU4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.05 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >5.01 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =2.5 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =10 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50.4 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~5.41 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =15 | mg/m3 | LOAEL | inhalation | Monkey | ToxValDB_TX_TCEQ |
| =25.1 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =25.2 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~25.43 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50.4 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50.5 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| <=80 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=1350 | mg/kg bw/day | LOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =2.679 | mg/m3 | LOAEL (ADJ) | inhalation | Monkey | ToxValDB_TX_TCEQ |
| =1.98 | mg/m3 | LOAEL (HEC) | inhalation | Monkey | ToxValDB_TX_TCEQ |
| =50 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =500 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =665 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Silicon dioxide | 231-545-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
33.8%
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
silicon dioxide
ChEMBL Phase
Not listed
Adverse Events
464
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E551 — FDA GRAS: At the notifier's request, FDA ceased to evaluate this notice
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Silica?
Silica appears on 20 regulatory/inventory lists including Pesticides, children; Europe; Personal care, children; Europe; Personal care - dental care - toothpaste, and 17 more. Source: EPA CPDat.
Is Silica a carcinogen according to IARC?
Silica is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1996). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Silica used in cosmetics?
Yes, Silica is also indexed as a cosmetic ingredient under the name Hydrolyzed Silica. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Silica come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Silica used outside industrial chemicals?
Silica also appears in cosmetics, pharmaceutical, food safety, cannabis databases.