Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Hydrolyzed Silica. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1600 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 1340 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1350 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
Expert Verdict
Good safety profile with negligible systemic exposure. Generally considered safe for cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is Hydrolyzed Silica safe in cosmetics?
Good safety profile with negligible systemic exposure. Generally considered safe for cosmetic use. The EU classifies Hydrolyzed Silica as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Hydrolyzed Silica allowed in the EU?
Hydrolyzed Silica EU regulatory status: permitted. Maximum allowed concentration: 33.8%. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrolyzed Silica do in cosmetics?
Hydrolyzed Silica functions as: Colorant. It is classified as a Cosmetic Ingredient in our database. CAS number: 7631-86-9.
What is the Margin of Safety for Hydrolyzed Silica?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydrolyzed Silica?
The NOAEL (No Observed Adverse Effect Level) for Hydrolyzed Silica is 1600 mg/kg bw/day based on a Developmental study via oral route in rabbit. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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