What is the GHS hazard classification for Sodium bisulfite?
Sodium bisulfite (CAS 7631-90-5) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium bisulfite
Also known as: Sodium sulfite (NaHSO3), hidrogenosulfito de sodio (solucion acuosa), Sodium bisulphite, Sodium hydrogensulfite (aqueous solution), Sulfurous acid, sodium salt (1:1) (+13 more)
CAS 7631-90-5
Sodium bisulfite (CAS 7631-90-5) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 24 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
34
SOURCE
chemical inventory jurisdictions
Regulatory lists
24
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Sodium bisulfite
CAS Number
7631-90-5
DTXSID
DTXSID8034902
Molecular Formula
Na.H2O3S
InChI Key
DWAQJAXMDSEUJJ-UHFFFAOYSA-M
Synonyms
Sodium sulfite (NaHSO3)hidrogenosulfito de sodio (solucion acuosa)Sodium bisulphiteSodium hydrogensulfite (aqueous solution)Sulfurous acid, sodium salt (1:1)Caswell No. 750EINECS 231-548-0EPA Pesticide Chemical Code 078201NSC 60680Sodium hydrosulfite(DOT)Sodium sulhydrateUantax SBS
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 * | H302 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Harmful if swallowed |
| Short-term Effects | The substance is irritating to the skin, eyes, respiratory tract and gastrointestinal tract. Exposure could cause asthma-like reactions or urticaria in sensitive persons. |
| Long-term Effects | Repeated or prolonged inhalation may cause asthma-like symptoms. The substance may have effects on the skin. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 5 mg/m³ | - | 5 | N |
| ACGIH | TWA | 5 mg/m³ [1992] | - | 5 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
41 records
Stabilizing agentPreservativeAntioxidantReducing agentHair waving or straighteningThickening agentProcessing aids not otherwise specifiedBiocideFlavouring and nutrientSurface modifierDyeFillerFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
24 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| fracking; water | NY Department of Conservation | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 34 of 34 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =246 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 15 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 18.8 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| TZX5469Z6I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TZX5469Z6I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TZX5469Z6I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TZX5469Z6I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.32 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =5 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| 100 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 110 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 120 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 150 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 200 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 206 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 246 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =2.5 | % | NOEL | oral | Rat | ToxValDB_ECOTOX |
| 89.1 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 91.1 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 100.2 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 63.5 | % | Viability (18 hours) | Dermal | - | NTP_ICE_skin_irritation |
| 42.3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 47.4 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 93.8 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 71.3 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 89.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 94.9 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 41.6 | % | Viability (42 hours) | Dermal | - | NTP_ICE_skin_irritation |
| 54.2 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 67.6 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 92.8 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 34 of 34 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium hydrogensulfite | 231-548-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.2%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM BISULFITE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E222 — ADI: 0.7 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Sodium bisulfite?
Sodium bisulfite has 34 NOAEL studies in the database. The lowest reported value is 15 min via Dermal. Source: NTP_ICE_skin_irritation.
What regulatory lists include Sodium bisulfite?
Sodium bisulfite appears on 8 regulatory/inventory lists including SCIL (9/2019), fracking; water, active_ingredient; Pesticides, and 5 more. Source: EPA CPDat.
What are the occupational exposure limits for Sodium bisulfite?
Occupational exposure limits for Sodium bisulfite are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Sodium bisulfite used in cosmetics?
Yes, Sodium bisulfite is also indexed as a cosmetic ingredient under the name Sodium Bisulfite. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium bisulfite come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Sodium bisulfite used outside industrial chemicals?
Sodium bisulfite also appears in cosmetics, pharmaceutical, food safety, cannabis databases.