Danger GHS04GHS06GHS05 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

Hydrochloric acid

Also known as: HCl, 4-D Bowl Sanitizer, Aqueous hydrogen chloride, Bowl Cleaner, Caswell No. 486 (+15 more)

CAS 7647-01-0

Hydrochloric acid (CAS 7647-01-0) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H314. Key regulatory status: REACH registered, 45 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, OSHA, EPA TRI.

View cosmetic safety profile for Hydrochloric Acid →

Cross-Vertical Regulatory Divergence

Hydrochloric acid is classified GHS Danger (H331, H314) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Hydrochloric acid

CAS Number

7647-01-0

DTXSID

DTXSID2020711

Molecular Formula

ClH

InChI Key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

Monoisotopic Mass

35.976678

Synonyms

HCl4-D Bowl SanitizerAqueous hydrogen chlorideBowl CleanerCaswell No. 486EINECS 231-595-7Emulsion Bowl CleanerEPA Pesticide Chemical Code 045901Hygeia Creme Magic Bowl CleanerNow South Safti-Sol Brand Concentrated Bowl Cleanse with Magic ActioPercleen Bowl and Urinal CleanerVarley's Ocean Blue Scented Toilet Bowl Cleaner

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1991	54

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Press. Gas; Acute Tox. 3 *; Skin Corr. 1A	H331; H314	GHS04; GHS06; GHS05	Danger

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 9 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	CEILING	5 ppm (7 mg/m³)	5	7	N
NIOSH	CEILING	5 ppm (7 mg/m³)	5	7	N
ACGIH	CEILING	2 ppm [2000]	2	-	N
CAL/OSHA	TWA	0.3 ppm (0.45 mg/m³)	0.3	0.45	N
CAL/OSHA	CEILING	2 ppm	2	-	N
NIOSH	IDLH	50 ppm	50	-	-
AIHA	ERPG-1	3 ppm	3	-	-
AIHA	ERPG-2	20 ppm	20	-	-
AIHA	ERPG-3	150 ppm	150	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

pH regulating agentCleaning agentAnti-scaling agentChelating agentProcessing aids not otherwise specifiedOtherBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 45 records

List	Keyword	Source
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Europe; Personal care - hair styling and care - shampoo-dandruff	Danish Environmental Protection Agency	Danish EPA
animal_products	USDA	United States Department of Agriculture (USDA)
Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
fracking	FracFocus	FracFocus
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
fracking; water	NY Department of Conservation	CPCat
pharmaceutical	US International Trade Commission	CPCat
Pesticides	National Park Service	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; Pesticides	EPA	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 84 studies

Value	Unit	Endpoint	Route	Species	Source
9.09	min	Breakthrough Time	Dermal	-	NTP_ICE_skin_irritation
QTT17582CB	UNII	FDA UNII substance identifier	-	-	openFDA substances
QTT17582CB	UNII	FDA UNII substance identifier	-	-	openFDA substances
QTT17582CB	UNII	FDA UNII substance identifier	-	-	openFDA substances
QTT17582CB	UNII	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
4.6556	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
5.514	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
7.004	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
7.0043	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
7.0058	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
8.3	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
8.3456	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
45	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
45.6	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
46.1986	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
60.938	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
61.085	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
61.1014	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=14.9121	mg/m3	LOAEL	inhalation	Rat	ToxValDB_Cal_OEHHA_REL_derivations
=15	mg/m3	LOAEL	inhalation	Rat	ToxValDB_IRIS
=2.7	mg/m3	LOAEL (ADJ)	inhalation	Rat	ToxValDB_IRIS
=6.1	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_IRIS
=6.1	mg/m^3	LOAEL (HEC)	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=25	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=50	mM	LOEL	oral	Rat	ToxValDB_ECOTOX
=100	mM	LOEL	oral	Rat	ToxValDB_ECOTOX
=150	mM	LOEL	oral	Rat	ToxValDB_ECOTOX
=350	mM	LOEL	oral	Rat	ToxValDB_ECOTOX
=500	mM	LOEL	oral	Rat	ToxValDB_ECOTOX
=2.68419	mg/m3	NOAEL	inhalation	Human	ToxValDB_Cal_OEHHA_REL_derivations
122	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
360	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB
433	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1325	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1607	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1669	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1800	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
1866	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
18	%	Positive reaction	Dermal	Human	NTP_ICE_skin_irritation
5	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization
=0.02	mg/m3	RfC	inhalation	Human	ToxValDB_IRIS
=0.02	mg/m^3	RfC	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
0.6	kiloohms	TER	Dermal	-	NTP_ICE_skin_irritation

Showing 50 of 84 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Hydrogen chloride	231-595-7	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Hydrochloric acid (acid aerosols)	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL HYDROCHLORIC ACID

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E507 — ADI: NOT LIMITED mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Hydrochloric acid?

Hydrochloric acid (CAS 7647-01-0) is classified under EU CLP Annex VI as Press. Gas; Acute Tox. 3 *; Skin Corr. 1A with signal word Danger. Hazard statements: H331; H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Hydrochloric acid?

Hydrochloric acid has 84 NOAEL studies in the database. The lowest reported value is 9.09 min via Dermal. Source: NTP_ICE_skin_irritation.

What regulatory lists include Hydrochloric acid?

Hydrochloric acid appears on 16 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 13 more. Source: EPA CPDat.

Is Hydrochloric acid a carcinogen according to IARC?

Hydrochloric acid is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1991). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for Hydrochloric acid?

Occupational exposure limits for Hydrochloric acid are set by OSHA, NIOSH, ACGIH. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Hydrochloric acid used in cosmetics?

Yes, Hydrochloric acid is also indexed as a cosmetic ingredient under the name Hydrochloric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hydrochloric acid come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Hydrochloric acid have different safety status in cosmetics vs industrial chemicals?

Hydrochloric acid is classified GHS Danger (H331, H314) in the chemicals database but is restricted in EU cosmetics.

Is Hydrochloric acid used outside industrial chemicals?

Hydrochloric acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.