Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Hydrochloric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 433 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1800 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| NOAEL | 360 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 1607 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1325 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1866 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1669 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 122 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 360 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| dose_tested | 1607 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Concentrated form is highly corrosive (GHS H314, H335). Safe only as a processing aid for pH adjustment with negligible residual HCl in finished product. Final product pH must fall within safe range and be documented with required worker safety protocols during manufacturing.
Regulatory Flags
Frequently Asked Questions
Is Hydrochloric Acid safe in cosmetics?
Concentrated form is highly corrosive (GHS H314, H335). Safe only as a processing aid for pH adjustment with negligible residual HCl in finished product. Final product pH must fall within safe range and be documented with required worker safety protocols during manufacturing. The EU classifies Hydrochloric Acid as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Hydrochloric Acid allowed in the EU?
Hydrochloric Acid EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrochloric Acid do in cosmetics?
Hydrochloric Acid functions as: Buffering / pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 7647-01-0.
What is the Margin of Safety for Hydrochloric Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydrochloric Acid?
The NOAEL (No Observed Adverse Effect Level) for Hydrochloric Acid is 433 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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