NOAEL Data REACH Registered Cosmetic Ingredient

Sodium chloride

Also known as: Sodium Chloride (Table Salt), Sodium chloride (NaCl), EC No.: 231-598-3, Alberger salt, Ayr (+15 more)

CAS 7647-14-5

Sodium chloride (CAS 7647-14-5) is a chemical substance. Key regulatory status: REACH registered, 56 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Sodium Chloride →

Cross-Vertical Regulatory Divergence

Sodium chloride is classified GHS Danger (H319, H318, H412) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields

Name

Sodium chloride

CAS Number

7647-14-5

Molecular Formula

ClH.Na

InChI Key

FAPWRFPIFSIZLT-UHFFFAOYSA-M

Synonyms

Sodium Chloride (Table Salt)Sodium chloride (NaCl)EC No.: 231-598-3Alberger saltAyrCaswell No. 754EINECS 231-598-3EPA Pesticide Chemical Code 013905Extra Fine 200 SaltExtra Fine 325 SaltHyposalineTrisodium trichloride

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Viscosity modifierSurfactant (surface active agent)Chelating agentFillerAbrasiveProcessing aids not otherwise specifiedPharmaceutical excipientThickening agentHumectantDeodorizerSoftener and conditionerBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 56 records

List	Keyword	Source
detected; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe	Danish EPA	Danish EPA
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	US International Trade Commission	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Europe; supplements	EU	CPCat
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - oven - oven cleaner; Europe	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - body hygiene - body wash	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 60 studies

Value	Unit	Endpoint	Route	Species	Source
<=5	mg/kg	ADI	oral	Human	WHO/JECFA
=2069	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
451W47IQ8X	UNII	FDA UNII substance identifier	-	-	openFDA substances
L8527B28XP	UNII	FDA UNII substance identifier	-	-	openFDA substances
VR5Y7PDT5W	UNII	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
>42	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=0.25	%	LOEL	oral	Rat	ToxValDB ECOTOX
=1	%	LOEL	oral	Rat	ToxValDB ECOTOX
=2	%	LOEL	oral	Rat	ToxValDB ECOTOX
=2.02	% diet	LOEL	oral	Rat	ToxValDB ECOTOX
=3.12	%	LOEL	oral	Rat	ToxValDB ECOTOX
=4.5	mM/kg	LOEL	injection	Dog	ToxValDB ECOTOX
=6	%	LOEL	oral	Rat	ToxValDB ECOTOX
=8	%	LOEL	oral	Rat	ToxValDB ECOTOX
=10	%	LOEL	oral	Rat	ToxValDB ECOTOX
=12	%	LOEL	oral	Rat	ToxValDB ECOTOX
=25	%	LOEL	oral	Rat	ToxValDB ECOTOX
=50	mmol/kg diet	LOEL	oral	Rat	ToxValDB ECOTOX
=400	mg/kg bw/day	LOEL	oral	Rat	ToxValDB ECOTOX
=460	mg/kg bw/day	LOEL	oral	Rat	ToxValDB ECOTOX
=500	mg/kg bw/day	LOEL	oral	Rat	ToxValDB ECOTOX
=1000	mg/kg bw/day	LOEL	oral	Rat	ToxValDB ECOTOX
=1300	mM	LOEL	oral	Rat	ToxValDB ECOTOX
=2600	mM	LOEL	oral	Rat	ToxValDB ECOTOX
250	mg/kg bw/day	NOAEL	oral	swine	COSMOS DB
368	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
480	mg/kg bw/day	NOAEL	oral	mouse	COSMOS DB
500	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
800	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
1010	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
1250	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
1500	mg/kg bw/day	NOAEL	oral	monkey	COSMOS DB
1900	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
2000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
2500	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
2690	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
3000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
3085	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
3500	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
3850	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
3949	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
4000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
5000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
5500	mg/kg bw/day	NOAEL	oral	dog	COSMOS DB
5600	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
7000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
7700	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
7760	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB

Showing 50 of 60 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Sodium chloride	231-598-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed SODIUM CHLORIDE

ChEMBL Phase

Adverse Events

8600

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Sodium chloride?

Sodium chloride has 60 NOAEL studies in the database. The lowest reported value is 5 mg/kg via oral in Human. Source: WHO/JECFA.

What regulatory lists include Sodium chloride?

Sodium chloride appears on 26 regulatory/inventory lists including detected; Other direct contact consumer goods, Canada; pharmaceutical, Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe, and 23 more. Source: EPA CPDat.

Is Sodium chloride used in cosmetics?

Yes, Sodium chloride is also indexed as a cosmetic ingredient under the name Sodium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium chloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Sodium chloride have different safety status in cosmetics vs industrial chemicals?

Sodium chloride is classified GHS Danger (H319, H318, H412) in the chemicals database but is allowed in EU cosmetics.

Is Sodium chloride used outside industrial chemicals?

Sodium chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.