Excellent Cosmetic Ingredient NOAEL Data

Sodium Chloride

CAS Number
7647-14-5
Function
Viscosity modifier, thickening agent, isotonic adjuster, cleansing booster
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted; FDA GRAS; no cosmetic limitations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Sodium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1250 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 2690 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 17500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 3500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 3500 mg/kg bw/day oral dog Short Term Toxicity COSMOS_DB
NOAEL 5500 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 480 mg/kg bw/day oral mouse Developmental COSMOS_DB
NOAEL 368 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 368 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 3000 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Generally safe; can be drying or irritating at very high concentrations on compromised skin due to osmotic effects, but no restrictions apply at typical use levels.

⚠️
Concern Level: Low

Regulatory Flags

eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Sodium Chloride safe in cosmetics?

Generally safe; can be drying or irritating at very high concentrations on compromised skin due to osmotic effects, but no restrictions apply at typical use levels. The EU classifies Sodium Chloride as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Sodium Chloride allowed in the EU?

Sodium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Chloride do in cosmetics?

Sodium Chloride functions as: Viscosity modifier, thickening agent, isotonic adjuster, cleansing booster. It is classified as a cosmetic ingredient in our database. CAS number: 7647-14-5.

What is the Margin of Safety for Sodium Chloride?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Chloride?

The NOAEL (No Observed Adverse Effect Level) for Sodium Chloride is 1250 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Sodium Chloride compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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