Danger GHS04GHS06GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Ammonia

Also known as: Ammonia gas, Ammonia-14N, Caswell No. 041, EINECS 231-635-3, EPA Pesticide Chemical Code 005302 (+15 more)

CAS 7664-41-7

Ammonia (CAS 7664-41-7) is a chemical substance with GHS signal word Danger; key hazard signal: H221; H331; H314; H400. Key regulatory status: REACH registered, 29 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Ammonia →

Cross-Vertical Regulatory Divergence

Ammonia is classified GHS Danger (H221, H331, H314, H400) in the chemicals database but is restricted in EU cosmetics at max 6%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Ammonia

CAS Number

7664-41-7

Molecular Formula

H3N

InChI Key

QGZKDVFQNNGYKY-UHFFFAOYSA-N

Monoisotopic Mass

17.026549

Synonyms

Ammonia gasAmmonia-14NCaswell No. 041EINECS 231-635-3EPA Pesticide Chemical Code 005302AmmoniacaAmoniakAm-folAmmonia (conc 20% or greater)Ammonia anhydrousAmmonia inhalantAmmonia solution

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Gas 2; Press. Gas; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Acute 1	H221; H331; H314; H400	GHS04; GHS06; GHS05; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Flammable gas Contains gas under pressure; may explode if heated Toxic if inhaled Causes severe skin burns and eye damage Very toxic to aquatic life
Short-term Effects	Rapid evaporation of the liquid may cause frostbite. The substance is corrosive to the eyes, skin and respiratory tract. Exposure could cause asphyxiation due to swelling in the throat. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.
Long-term Effects	Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract. Lungs may be affected by repeated or prolongated exposure. This may result in chronic obstructive pulmonary disorders (COPD).
Routes of Exposure	The substance can be absorbed into the body by inhalation.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 9 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	50 ppm (35 mg/m³)	50	35	N
NIOSH	TWA	25 ppm (18 mg/m³)	25	18	N
NIOSH	STEL	35 ppm (27 mg/m³)	35	27	N
CAL/OSHA	TWA	25 ppm (17 mg/m³)	25	17	N
CAL/OSHA	STEL	35 ppm (27 mg/m³)	35	27	N
NIOSH	IDLH	300 ppm	300	-	-
AIHA	ERPG-1	25 ppm	25	-	-
AIHA	ERPG-2	150 ppm	150	-	-
AIHA	ERPG-3	1500 ppm	1500	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 41 records

DeodorizerpH regulating agentFragranceFlavouring and nutrientProcessing aids not otherwise specifiedPreservativeCleaning agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 29 records

List	Keyword	Source
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
-	Journal of Chemical Engineering & Process Technology	Published Articles
Europe; Personal care; restricted	European Commission	CosIng
Europe	European Commission	Fl@vis
Canada; pharmaceutical	DrugBank	DrugBank
fracking; water	NY Department of Conservation	CPCat
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
fracking; water	NY Department of Conservation	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 64 studies

Value	Unit	Endpoint	Route	Species	Source
=9.473	mg/m3	BMC (05)	inhalation	Human	ToxValDB Cal OEHHA REL derivations
=14	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
=47.6	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
5138Q19F1X	UNII	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
1	unitless	GHS Classification	Ocular	Rabbit	NTP ICE eye irritation
1.392	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
5.108	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
6.613	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
7.035	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
7.04	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
7.939	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
9.806	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
9.85	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
11.34	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
11.56	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
11.59	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
12.11	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
12.2	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
13.71	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
13.77	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
14.13	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
14.17	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
16.52	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
17.76	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
18.6	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
18.69	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
19.91	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
19.96	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
22.74	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
25.82	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
28.05	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
28.13	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
31.29	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
4673	mg/m3	LC50	Inhalation	-	NTP ICE acute inhalation
=348.3	mg/m3	LEL	inhalation	Human	ToxValDB NIOSH IDLH
=1.045e+5	mg/m3	LEL	inhalation	Human	ToxValDB DOE Protective Action Criteria
=2	ppm	LOAEL	-	-	WHO/JECFA
=3.483	mg/m3	LOAEL	inhalation	Human	ToxValDB TX TCEQ
=10	ppm	LOAEL	-	-	WHO/JECFA
=34.83	mg/m3	LOAEL	inhalation	Human	ToxValDB ATSDR MRLs
=34.83	mg/m3	LOAEL	inhalation	Human	ToxValDB EU SCOEL
=34.83	mg/m3	LOAEL	inhalation	Human (M/F)	Regulatory source
=62.69	mg/m3	LOAEL	inhalation	Rat	ToxValDB HPVIS
=143	ppm	LOAEL	inhalation	Rat	WHO/JECFA
=0.01	%	LOEL	oral	Rat	ToxValDB ECOTOX
=0.02	%	LOEL	oral	Rat	ToxValDB ECOTOX
=0.1	%	LOEL	oral	Rat	ToxValDB ECOTOX
=20	g/kg sd	LOEL	oral	Rat	ToxValDB ECOTOX
=187.5	mM	LOEL	oral	Rat	ToxValDB ECOTOX

Showing 50 of 64 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Ammonia, anhydrous	231-635-3	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Ammonia	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed AMMONIA SOLUTION, STRONG

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Ammonia?

Ammonia (CAS 7664-41-7) is classified under EU CLP Annex VI as Flam. Gas 2; Press. Gas; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Acute 1 with signal word Danger. Hazard statements: H221; H331; H314; H400. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ammonia?

Ammonia has 64 NOAEL studies in the database. The lowest reported value is 0.01 % via oral in Rat. Source: ToxValDB ECOTOX.

What regulatory lists include Ammonia?

Ammonia appears on 14 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, Indirect additives food contact (10/2018), and 11 more. Source: EPA CPDat.

What are the occupational exposure limits for Ammonia?

Occupational exposure limits for Ammonia are set by OSHA, NIOSH, CAL/OSHA. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Ammonia used in cosmetics?

Yes, Ammonia is also indexed as a cosmetic ingredient under the name Ammonia. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ammonia come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Ammonia have different safety status in cosmetics vs industrial chemicals?

Ammonia is classified GHS Danger (H221, H331, H314, H400) in the chemicals database but is restricted in EU cosmetics at max 6%.

Is Ammonia used outside industrial chemicals?

Ammonia also appears in cosmetics, pharmaceutical, cannabis databases.