Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Ammonia

Also known as: Ammonia gas, Ammonia-14N, Caswell No. 041, EINECS 231-635-3, EPA Pesticide Chemical Code 005302 (+15 more)

INCI: AMMONIA

Ammonia (CAS 7664-41-7) is a cosmetic cosmetic ingredient functioning as pH adjuster, buffering agent. Reported NOAEL =256 mg/kg/day (CIR_vision_codex); EU Regulation 1223/2009 status: restricted, max 6%; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 7664-41-7 →

Auto-generated CPSR Part A draft with source citations
CAS Number
7664-41-7
View industrial chemical safety profile →
Function
pH adjuster, buffering agent
Safety Rating
MODERATE

Chemistry & Identifiers

EC Number
231-635-3
ChEBI: CHEBI:16134 UNII: 5138Q19F1X Wikidata: Q4087

Regulatory Status

EU EU Status restricted
EU Max Conc. 6%
US US Status permitted
US Notes Permitted; no specific concentration limits under FDA. Subject to general safety requirements under MoCRA.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Ammonia.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Ammonia. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =256 mg/kg/day oral - developmental toxicity CIR_vision_codex
NOAEL =256 mg/kg/day oral - developmental toxicity CIR_vision_codex
NOAEL =256 mg/kg/day oral - developmental toxicity CIR_vision_codex
NOAEL =256 mg/kg/day oral - developmental toxicity CIR_vision_codex
NOAEL =1500 mg/kg/day oral rat developmental toxicity CIR_vision_codex
NOAEL =1500 mg/kg/day oral rat developmental toxicity CIR_vision_codex
NOAEL =1500 mg/kg/day oral rat developmental toxicity CIR_vision_codex
NOAEL =1500 mg/kg/day oral rat developmental toxicity CIR_vision_codex

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
CylinderGasSkullToxicCorrEnviroAqua
Hazard Statements
Flammable gas Contains gas under pressure; may explode if heated Toxic if inhaled Causes severe skin burns and eye damage Very toxic to aquatic life
Short-term Exposure Effects
Rapid evaporation of the liquid may cause frostbite. The substance is corrosive to the eyes, skin and respiratory tract. Exposure could cause asphyxiation due to swelling in the throat. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.
Long-term Exposure Effects
Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract. Lungs may be affected by repeated or prolongated exposure. This may result in chronic obstructive pulmonary disorders (COPD).
Routes of Exposure
The substance can be absorbed into the body by inhalation.

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word
Danger
Pictograms
Compressed GasAcute ToxicityCorrosiveEnvironmental Hazard
Hazard Class and Category
Flam. Gas 2; Press. Gas; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Acute 1
Hazard Statements
  • H221 Flammable gas
  • H331 Toxic if inhaled
  • H314 Causes severe skin burns and eye damage
  • H400 Very toxic to aquatic life

Inserted via ATP: CLP00

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
10,000,000 - 100,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

JPKR Japan/Korea Cosmetics
Korea (Restricted): max 6.0
Additional Jurisdictional Restrictions (3)
Jurisdiction Status Max % Product Type
AU restricted - hair dyes
BR restricted 6 All cosmetic products (calculated as NH3)
ASEAN restricted 6% as NH3 All products

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Cleaning agent Deodorizer Flavouring and nutrient Fragrance Preservative Processing aids not otherwise specified pH regulating agent
Regulatory List Membership (2)
FDA Indirect Food Contact Additives EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for Ammonia.

Regulatory Flags

endocrine_disruptor eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Ammonia by CAS number or substance name.

Studies
8
Lowest NOAEL
256 mg/kg/day
Highest NOAEL
1500 mg/kg/day
CIR_vision_codex

Known Synonyms

Ammonia gas Ammonia-14N Caswell No. 041 EINECS 231-635-3 EPA Pesticide Chemical Code 005302 Ammoniaca Amoniak Am-fol Ammonia (conc 20% or greater) Ammonia anhydrous Ammonia inhalant Ammonia solution Ammonia solution strong (NF) Ammonia solution strong [usan] Ammonia water Ammonia water (JP15) Ammoniac [french] Ammoniaca [italian] Ammoniacum gummi Ammoniak [german]

Chemical Function

Deodorizer pH regulating agent Fragrance Flavouring and nutrient Processing aids not otherwise specified

Regulatory Lists

drinking_water; Europe; manufacturing; plastic_additive active_ingredient; Pesticides Indirect additives food contact (10/2018) active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides Europe; Vehicle - car interior consumer_product; Europe air; detected; emissions; Europe; Other direct contact consumer goods Australia; Food and drug - smoking-related products Journal of Chemical Engineering & Process Technology Europe; Personal care; restricted

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound
AMMONIA SOLUTION, STRONG
ChEMBL ID
CHEMBL1160819
Max Phase
4
Adverse Event Associations
1
View full pharmaceutical profile →

Frequently Asked Questions

Is Ammonia safe in cosmetics?

Ammonia has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.

Is Ammonia allowed in the EU?

Ammonia EU regulatory status: restricted. Maximum allowed concentration: 6%. This is based on EU Regulation 1223/2009 and its amendments.

What does Ammonia do in cosmetics?

Ammonia functions as: pH adjuster, buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 7664-41-7.

What is the NOAEL for Ammonia?

The NOAEL (No Observed Adverse Effect Level) for Ammonia is =256 mg/kg/day based on a developmental toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: CIR_vision_codex.

Is Ammonia classified as hazardous under GHS?

Ammonia carries a GHS signal word of "DANGER". Hazard statements: Flammable gas Contains gas under pressure; may explode if heated Toxic if inhaled Causes severe skin burns and eye damage Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Is Ammonia used outside cosmetics?

Ammonia also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Ammonia have different safety status in cosmetics vs industrial chemicals?

Ammonia is classified GHS Danger (H221, H280, H314, H331, H332, H335, H400, H411) in the chemicals database but is restricted in EU cosmetics at max 6%.

Compliance Tools

Check Ammonia compliance across multiple jurisdictions:

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MoS Calculator
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