What is the NOAEL for Acetyl tributyl citrate?
Acetyl tributyl citrate has 27 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetyl tributyl citrate
Also known as: 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester, 2-(Acetyloxy)-1,2,3-tributyloate-1,2,3-propanetricarboxylic acid, Acetylcitric acid, tributyl ester, BRN 2303316, Caswell No. 005AB (+6 more)
CAS 77-90-7
Acetyl tributyl citrate (CAS 77-90-7) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
27
SOURCE
Chemical inventory jurisdictions
Regulatory lists
11
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
16 fields
Name
Acetyl tributyl citrate
CAS Number
77-90-7
Molecular Formula
C20H34O8
InChI Key
QZCLKYGREBVARF-UHFFFAOYSA-N
Monoisotopic Mass
402.225368
Synonyms
1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester2-(Acetyloxy)-1,2,3-tributyloate-1,2,3-propanetricarboxylic acidAcetylcitric acid, tributyl esterBRN 2303316Caswell No. 005ABEINECS 201-067-0FEMA No. 3080Tributyl acetyl citrateTributyl 2-(acetyloxy)-1,2,3-propanetricarboxylateUNII-0ZBX0N59RZAcetyltributylcitrate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
53 records
PlasticizerDeodorizerFragranceFilm formerFlavouring and nutrientSolventAdhesion/cohesion promoterStabilizing agentProcessing aids not otherwise specifiedLubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 27 of 27 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 261 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| =7.04 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =7.05 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 0ZBX0N59RZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.00942 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =3.140e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 199 | mg/kg bw/day | LOAEL | oral | mouse | COSMOS DB |
| 300 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| >=100 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =100 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 1780 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| ~2000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 2495 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 2623 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 5000 | mg/kg bw/day | NOAEL | oral | cat | COSMOS DB |
| <5 | mg/kg bw/day | NOEL | oral | Cat | ECHA |
| =250 | mg/kg bw/day | NOEL | oral | Mouse | ECHA |
| =300 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 27 of 27 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tributyl O-acetylcitrate | 201-067-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ACETYLTRIBUTYL CITRATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Acetyl tributyl citrate?
Acetyl tributyl citrate appears on 10 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe, and 7 more. Source: EPA CPDat.
Is Acetyl tributyl citrate used in cosmetics?
Yes, Acetyl tributyl citrate is also indexed as a cosmetic ingredient under the name Acetyl Tributyl Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetyl tributyl citrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Acetyl tributyl citrate used outside industrial chemicals?
Acetyl tributyl citrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.